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ProteomicsSerum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs
Development and progression of myxomatous mitral valve disease (MMVD) in domestic dogs is unpredictable and pathobiology still unclear. The American College of Veterinary Internal Medicine (ACVIM) perceived that mayor improvement in management of diseased dogs would be timely diagnosis, especially d...
ORGANISM(S): Bos taurus (Bovine) 
2023-05-10 | PXD038475 | Pride
Myxomatous mitral valve disease Degenerative mitral valve disease Tmt proteomics Dogs Serum 
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
GenomicsMitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease
Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease
PRJNA900263 | ENA
TranscriptomicsAffymetrix GeneChip™ Canine Gene 1.1ST Array of canine heart valves in all stages of Myxomatous mitral valve disease (Normal-4)
Whole mitral valves from each Whitney grade of disease; normal (n=6), grade 1 (n=5), grade 2 (n=6), grade 3 (n=6) and grade 4 (n=5). mRNA was extracted using the qiagen RNeasy minikit and assessed by the agilent 2200 bioanalsyser. all samples passed quality control and transcriptomic analysis was pe...
ORGANISM(S): Canis lupus familiaris 
2019-12-26 | E-MTAB-8618 | biostudies-arrayexpress
GenomicsMyxomatous Mitral Valve Degeneration Associated with Elastin Accumulation in LTBP2-Deficient Mice
Myxomatous Mitral Valve Degeneration Associated with Elastin Accumulation in LTBP2-Deficient Mice
PRJNA1514404 | ENA
TranscriptomicsCirculating microRNA profiling by array in dogs with myxomatous mitral valve degeneration (MMVD) and pulmonic stenosis (PS) compared with healthy dogs
In this study, we aimed to demonstrate expression profiles of circulating microRNAs (miRNAs) in dogs with eccentric or concentric cardiac hypertrophy, and investigate whether there is a difference in miRNA expression according to the type of cardiac hypertrophy. Dogs with myxomatous mitral valve deg...
ORGANISM(S): Canis lupus familiaris 
2021-03-24 | E-MTAB-10029 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse deficient for Fibrillin-1
Different fibrillin-1 mutant mice
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1852 | biostudies-arrayexpress
TranscriptomicsMyxomatous Mitral Valve Degeneration Associated with Elastin Accumulation in LTBP2-Deficient Mice
Background: Mitral valve prolapse (MVP) is a common valvular heart disease associated related to substantial morbidity and potential mortality. The molecular mechanisms underlying disease development remain incompletely understood. We previously identified a large family in which a missense variant ...
ORGANISM(S): Mus musculus 
2026-08-26 | GSE344076 | GEO
GenomicsmTOR signal in mitral valve diseases
mTOR signal in mitral valve diseases
PRJNA1247445 | ENA
UnknownMyxomatous mitral valve disease bench to bedside: LDL-density-pressure regulates Lrp5.
Not available
S-EPMC4048944 | biostudies-literature
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