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GenomicsTransposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
Transposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
PRJNA833459 | ENA
ProteomicsDiscovering the N-terminal Methylome by the Repurposing of Proteomic Datasets
Protein ⍺-N-methylation is a cryptic and relatively unexplored post-translational modification involving the covalent addition of methyl groups to the free a-amino group at protein N-termini. To systematically explore the extent of ⍺-N-terminal methylation in yeast and humans, we utilized a repurpos...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-05-26 | PXD022833 | Pride
Proteomics Post-translational modification Repurposing ⍺-n-terminal methylation 
TranscriptomicsCTD tyrosine phosphorylation impairs termination factor recruitment to transcribing RNA polymerase II
ChIP-chip was performed to identify the genomic binding locations for the termination factors Nrd1, and Rtt103, and for RNA polymerase (Pol) II phosphorylated at the tyrosine 1 and threonine 4 position of its C-terminal domain (CTD). In different phases of the transcription cycle, Pol II recruits di...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-29 | E-MTAB-1060 | biostudies-arrayexpress
ProteomicsRegulation of Glycogen Synthase kinase 3beta by phosphorylation and O-beta-linked N-acetylglucosaminylation: implications on tau protein phosphorylation
Glycogen synthase kinase 3 (GSK3) plays a pivotal role in signaling pathways related to insulin metabolism and in the pathogenesis of Alzheimer s disease (AD) and other neurodegenerative disorders. More particularly, the GSK3beta isoform is involved in AD-associated tau pathology as one of the major...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-09 | MSV000094049 | MassIVE
OtherTransposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
DNA transposon systems are widely used in mammalian cells for genetic modification experiments, but their regulation remains poorly understood. We used biochemical and cell-based assays together with AlphaFold modeling and rational protein redesign to evaluate aspects of piggyBac transposition inclu...
ORGANISM(S): Homo sapiens 
2022-11-10 | GSE201914 | GEO
Proteomics5′ UTR length regulates the production of alternative N-terminal protein isoforms in health and disease
The 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a direct role in alternative N-terminal protein isoform production by...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD073007 | Pride
Cfd Translation initiation Alternative n-terminal isoform 
GenomicsDistinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
PRJNA1013251 | ENA
ProteomicsCombined assessment of global proteome, phosphoproteome and N-terminal protein cleavage to characterize altered platelet functions in human Scott syndrome
The Scott syndrome is a rare bleeding disorder associated with a mutation in the gene encoding anoctamin-6 (TMEM16F). After stimulation of Ca2+-mobilizing agonists, syndromatic platelets show a reduced phosphatidylserine exposure and do not form membrane blebs. Given the central role of anoctamin-6 ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD002883 | Pride
Phosphoproteome Human platelets N-terminal chafradic Lc-ms Proteome 
Unknownp53 N-terminal phosphorylation: a defining layer of complex regulation.
Not available
S-EPMC3499055 | biostudies-literature
OtherDistinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short unstructured N-terminal region of cofilin is critical for actin binding and harbors the major site of inhibitory phosphorylation. Atypically for a disordered...
ORGANISM(S): Saccharomyces cerevisiae 
2023-11-18 | GSE242403 | GEO
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