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ProteomicsNHE1 phosphorylation analysis in cardiomyocytes in normoxic and anoxic conditions
Na+/H+ exchanger 1 (NHE1; SLC9A1) is a transport protein responsible for pH regulation in various types of cells. In cardiac myocytes, NHE1 generates the largest transmembrane acid-extrusion flux and is therefore the most significant controller of the intracellular acid/base milieu. The protein itse...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-26 | PXD022853 | Pride
Phosphorylation Na+/h+ exchanger 1 Anoxic 
TranscriptomicsExpression data in single and double knockouts of AtNHX5 and AtNHX6 in Arabidopsis
We generated single and double knockouts of AtNHX5 and AtNHX6 in order to invesigate possible functions in Arabidopsis. nhx5/nhx6 exhibited severe growth retardation related to cell size and proliferation, as well as endosomal trafficking perutrbations. The results implicate endosomal NHX antiporter...
ORGANISM(S): Arabidopsis thaliana 
2012-01-01 | E-GEOD-23210 | biostudies-arrayexpress
UnknownStimulation of Na(+)/H(+) exchanger isoform 1 promotes microglial migration.
Not available
S-EPMC3749130 | biostudies-literature
UnknownCD44 targets Na(+)/H(+) exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2.
Not available
S-EPMC3929887 | biostudies-literature
TranscriptomicsGene Expression Profile of NHE1 Null Mutation
Effect of NHE1 null mutation on gene expression in different brain regions Keywords = NHE1 null mutation Keywords = gene expression Keywords = microarray Keywords = brain Keywords = mouse
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-1013 | biostudies-arrayexpress
UnknownZinc finger E-box binding homeobox-1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ Exchanger-1 (NHE1).
Not available
S-EPMC5731239 | biostudies-literature
TranscriptomicsElevated Myocardial Na+/H+ Exchanger Elicits the Expression of Genes that Lead to Cardiac Hypertrophy
In myocardial disease, elevated expression and activity of Na+/H+ exchanger isoform 1 (NHE1) is detrimental. To better understand the involvement of NHE1, transgenic mice with elevated heart-specific NHE1 expression were studied. N-line mice expressed wild-type NHE1 and K-line mice expressed activat...
ORGANISM(S): Mus musculus 
2010-05-17 | GSE19819 | GEO
MetabolomicsCardiac untargeted lipidomics in cardiomyocyte-specific SREBP1 knockdown mice

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13696 | MetaboLights
UnknownThe calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylation.
Not available
S-EPMC2723990 | biostudies-literature
UnknownA mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens.
Not available
S-EPMC1298952 | biostudies-literature
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