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ProteomicsFAX-RIC enables robust RNA interactome profiling in multicellular organisms in vivo
Formaldehyde crosslinking based profiling of RNA interactome in the mosue tissue, liver.
ORGANISM(S): Mus musculus (Mouse) 
2020-11-25 | PXD022023 | Pride
Mouse liver rbp rna interactome 
ProteomicsFormaldehyde-crosslinking enables comprehensive profiling of in vivo RNA-interactome in UV-impermeable samples
Development of UV-crosslinking based RNA-interactome capture protocol have expanded the repertoire of RBPs. Apparent limitations of UV-crosslinking, however, have made the RBP profiling to be incomplete and inapplicable to many of the biological samples in physiological contexts. Here we developed f...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2020-11-25 | PXD010046 | Pride
Rbp formaldehyde 
ProteomicsGENE EXPRESSION DYNAMICS BEFORE AND AFTER ZYGOTIC GENOME ACTIVATION IN DROSOPHILA EARLY EMBRYOGENESIS
Post-transcriptional gene regulatory mechanisms are fundamental for the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution gene expression level change analysis in D...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD047784 | Pride
Drosophila Mzt Ubiquitin Rbp 
ProteomicsGene expression dynamics before and after zygotic gene activation in Drosophila early embryogenesis
Post-transcriptional gene regulatory mechanisms are fundamental to the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution total RNA-sequencing and quantitative mass ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD057383 | Pride
Drosophila mzt development 
ProteomicsEpigenetic resetting in the Parkinson's disease entail histone modification remodeling.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disrupted cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD067971 | Pride
Human Tmt Parkinson's Organoid Lc-ms/ms 
ProteomicsmiR-124 coordinates metabolic regulators acting at early stages of human neurogenesis
Metabolic dysregulation of neurons is associated with diverse human brain disorders. Metabolic reprogramming occurs during neuronal differentiation, but it is not fully understood which molecules regulate metabolic changes at the early stages of neurogenesis. In this study, we report that miR-124 is...
ORGANISM(S): Homo sapiens (Human) 
2024-10-13 | PXD042371 | Pride
Mirna Nerogenesis Human 
ProteomicsIdentification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication
Psoriasis is a chronic inflammatory disease characterized by hyperproliferation of keratinocytes and abnormal blood vessels. As hyperproliferation is driven by pro-inflammatory cytokines produced by activated immune cells, therapeutic strategies often target these cytokines to manage the disease. Ho...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD058810 | Pride
Human oxidation eclipse 
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