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ProteomicsInfluenza A virus-induced production of PI4P at the endoplasmic reticulum involves ATG16L1 and promotes the egress of viral ribonucleoproteins
To further understand the molecular mechanisms by which RAB11A is hijacked in IAV-infected cells, we sought to identify viral-induced changes in RAB11A interactome. To this end, we used a TurboID-based proximity labelling approach, most suitable for the detection of weak or transient protein-protein...
ORGANISM(S): Homo sapiens (Human) 
2025-06-19 | PXD053858 | Pride
Human Shotgun proteomics Turboid Influenza a virus 
ProteomicsThe RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication
Recent technical advances have resulted in a significant increase in our understanding of the RNA-binding protein (RBP) repertoire present within eukaryotic cells. A particular focus has been on the RBPs that interact with cellular polyadenylated mRNAs. However, recent studies utilising the same tec...
ORGANISM(S): Homo sapiens (Human) 
2024-04-16 | PXD049316 | Pride
Q exactive hf Rna-binding protein Influenza a virus Label free 
ProteomicsThe RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication
Recent technical advances have resulted in a significant increase in our understanding of the RNA-binding protein (RBP) repertoire present within eukaryotic cells. A particular focus has been on the RBPs that interact with cellular polyadenylated mRNAs. However, recent studies utilising the same tec...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WS/1933(H1N1)) 
2024-04-16 | PXD040783 | Pride
Q exactive hf Tmt10plex Eric protocol Rna-binding protein Influenza a virus 
Genomicsena-DATASET-IP-27-09-2016-09:44:13:032-494 - samples
We recruited 100 healthy, male donors of self-reported European descent (EUB) and 100 of self-reported African descent (AFB) (Ghent, Belgium). For each participant, peripheral blood mononuclear cells (PBMCs) were isolated from whole blood on Ficoll-Paque density gradients. Monocytes were then positi...
EGAD00001002714 | EGA
GenomicsGenome-wide genotyping data and exome sequencing of 100 European-descent and 100 African-descent Belgians used in the EGAS000010
The 100 European-descent (EUB) and 100 African-descent (AFB) Belgians studied were genotyped for a total of 4,301,332 SNPs on the Illumina HumanOmni5-Quad BeadChips. Whole-exome sequencing was carried out for the same 200 individuals with the Nextera Rapid Capture Expanded Exome kit, on the Illumina...
EGAD00010001131 | EGA
GenomicsGenetic control of the transcriptomic response of monocytes to bacterial and viral stimuli assessed by RNA-seq in Africans and Europeans
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the extent of population differences in immune responses, and their genetic and evolutionary determinants, remain undefined. Here, we characterized, using RNA-sequencing, the transcriptional response of primary mon...
EGAS00001001895 | EGA
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