Sort   by:  
 Page size 
TranscriptomicsGene expression profiles using microarrays in diaphragm of normal Beagle dogs and Beagle-based canine muscular dystrophy (CXMDJ) before and 1 hour after initial respiration.
Canine muscular dystrophy (CXMDJ) is a dog model of the lethal X-linked muscle disorder Duchenne muscular dystrophy (DMD), which is caused by loss of dystrophin. Gene expression profile was analyzed in the diaphragm muscles of normal Beagle dogs and CXMDJ before and 1 hour after initial respiration....
ORGANISM(S): Canis lupus familiaris 
2012-10-31 | E-GEOD-32460 | biostudies-arrayexpress
ProteomicsRole of lncRNA-SPANXA2-OT1 in macrophage chemotaxis
Coronary artery disease (CAD) remains the leading cause of mortality worldwide. Macrophages play a crucial role in recruiting immune cells and regulating the inflammatory milieu through the release of a diverse array of cytokines, chemokines, and other immune mediators in CAD. Long noncoding RNAs (l...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD059474 | Pride
Lc-msms Human primary macrophage Coronary artery disease Long noncoding rna Inflammation 
UnknownMultiple common and rare variants of ABCG2 cause gout.

Objective

Previous studies have suggested an association between gout susceptibility and common dysfunctional variants in ATP-binding cassette transporter subfamily G member 2/breast cancer resistance protein (ABCG2/BCRP), including rs72552713 (Q126X) and rs2231142 (Q141K). However, t...
S-EPMC5706492 | biostudies-literature
ProteomicsIdentification of the components of PRDM14 complex in ESCs
We investigated the N-terminal domain of PRDM14, which has no discernable functional domain, and its contribution to the maintenance of pluripotency. We performed a mass spectrometry analysis of the PRDM14-containing complex to disclose partner molecules that bind to the N-terminal domain of PRDM14.
ORGANISM(S): Mus Musculus (mouse) 
PXD020571 | JPOST Repository
UnknownA meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility.
Not available
S-EPMC8866370 | biostudies-literature
UnknownGenome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

Objective

The first ever genome-wide association study (GWAS) of clinically defined gout cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout loci that aggravate AHUA into gout.

Methods

We carried out a GWAS of 945 clinically defined gout cases an...
S-EPMC6788923 | biostudies-literature
UnknownDysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels.
Not available
S-EPMC6937405 | biostudies-literature
UnknownSubtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.

Objectives

Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the las...
S-EPMC7213308 | biostudies-literature
UnknownStrong genetic effect on gout revealed by genetic risk score from meta-analysis of two genome-wide association studies.
Not available
S-EPMC11554751 | biostudies-literature
UnknownBiallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia.
Patatin-like phospholipase domain-containing lipase 8 (PNPLA8), one of the calcium-independent phospholipase A2 enzymes, is involved in various physiological processes through the maintenance of membrane phospholipids. Biallelic variants in PNPLA8 have been associated with a range of paediatric neur...
S-EPMC11531855 | biostudies-literature
Sort   by:  
 Page size