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ProteomicsLipid nanoparticles improves ex vivo gene editing of human hematopoietic cells
Ex-vivo gene editing in T cells and hematopoietic stem/progenitor cells (HSPCs) holds promise for treating diseases by non-homologous end joining (NHEJ) gene disruption or homology-driven repair (HDR) gene correction. Gene editing encompasses delivery of nucleases by electroporation and, when aiming...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037529 | Pride
Hunan Nanoparticles Hematopoietic cells 
TranscriptomicsMouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.
Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress
TranscriptomicsmiR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia
MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible mi...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-78078 | biostudies-arrayexpress
UnknownDeletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR.
Not available
S-EPMC275554 | biostudies-literature
TranscriptomicsRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Bulk transcriptome profiling of macrophages isolated from the spleen of control and tumor-bearing mice, treated or not with IFN gene therapy.
ORGANISM(S): Mus musculus 
2018-07-26 | E-MTAB-6482 | biostudies-arrayexpress
TranscriptomicsInterferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
Single-cell transcriptome profiling using a 3' droplet-based platform (Chromium,10x Genomics) of CD11b+ cells isolated from the spleen of control and tumor-bearing mice, treated or not with IFN gene therapy.
ORGANISM(S): Mus musculus 
2019-05-16 | E-MTAB-6487 | biostudies-arrayexpress
TranscriptomicsmiR-126 governs human leukemia stem cell quiescence and therapeutic resistance
In acute myeloid leukemia (AML), leukemia stem cells (LSC) play a central role in disease progression and recurrence due to their intrinsic capacity for self-renewal and chemotherapy resistance. Whereas epigenetic regulation balances normal blood stem cell self-renewal and fate decisions, mutation a...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-55770 | biostudies-arrayexpress
TranscriptomicsLentiviral vector-based insertional mutagenesis identifies new clinically relevant cancer genes involved in the pathogenesis of hepatocellular carcinoma
We devised a novel insertional mutagenesis approach based on lentiviral vectors to induce hepatocellular carcinoma in three mouse models and identified four novel cancer initiating genes. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose f...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-31409 | biostudies-arrayexpress
TranscriptomicsLentiviral vector-based insertional mutagenesis identifies new clinically relevant candidate cancer genes involved in the pathogenesis of hepatocellular carcinoma
We devised a novel insertional mutagenesis approach based on lentiviral vectors to induce hepatocellular carcinoma in three mouse models and identified four novel cancer initiating genes. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose f...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-GEOD-35986 | biostudies-arrayexpress
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