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The 26S proteasome recognizes substrates via ubiquitin receptors, a mechanism we leveraged to develop a small molecule ligand- and ubiquitination-independent targeted protein degradation strategy. Our proteasome-targeting chimera, Prote-a-Tac, links a proteasomal Ub receptor (PSMD4 or ADRM1) with a ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD063133 | Pride
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