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ProteomicsIntegrated Proteomic Profiling of Aqueous Humor Reveals CDC42/RHOA-Mediated Pathogenic Mechanisms in nAMD and PDR
Neovascular AMD (nAMD) and proliferative diabetic retinopathy (PDR) are major blinding retinal diseases characterized by pathological angiogenesis. Using data-independent acquisition (DIA) proteomics, we analyzed aqueous humor from nAMD, PDR, and cataract control patients. Among 3186 identified prot...
ORGANISM(S): Homo Sapiens 
PXD068217 |
ProteomicsThe Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease
In contrast to neovascular age-related macular degeneration (nAMD), no treatment option exists for dry AMD. The identification of specific biomarkers is required to facilitate diagnosis and therapy of dry AMD. We thus measured the proteome of 34 vitreous humor samples (dry AMD: n = 6, nAMD: n = 10, ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-23 | PXD008354 | Pride
Pdr Proliferative diabetic retinopathy Dry amd Age-related macular degeneration Neovascular amd Epiretinal membrane Vitreous proteome Human Biomarker Vitreous humor Namd Erm 
GenomicsUnraveling the web of nAMD: A transcriptomic analysis of age-related macular degeneration-associated cytokines in primary human retinal endothelial cells.
Unraveling the web of nAMD: A transcriptomic analysis of age-related macular degeneration-associated cytokines in primary human retinal endothelial cells.
PRJNA1126598 | ENA
TranscriptomicsUnraveling the web of nAMD: A transcriptomic analysis of age-related macular degeneration-associated cytokines in primary human retinal endothelial cells.
Neovascular age-related macular degeneration (nAMD) is a complex, blinding retinal disease underpinned by a dynamic and dysregulated interaction among pathogenic cytokines. The present study investigates the impact of six nAMD-associated cytokines, namely transforming growth factor-beta 1 and 2 (TGF...
ORGANISM(S): Homo sapiens 
2025-12-30 | GSE270418 | GEO
UnknownImplementation of Accelerated Molecular Dynamics in NAMD.
Not available
S-EPMC3115733 | biostudies-literature
UnknownScalable molecular dynamics on CPU and GPU architectures with NAMD.
Not available
S-EPMC7395834 | biostudies-literature
ProteomicsMolecular biomarkers of neovascular age-related macular degeneration with incomplete response to anti-vascular endothelial growth factor treatment
The standard treatment for neovascular age-related macular degeneration (nAMD) consists of intravitreal anti-vascular endothelial growth factors (VEGF). However, for some patients, even maximal anti-VEGF treatment does notentirely suppress exudative activity. The goal of this study was to identify m...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD022471 | Pride
Human Age-related macular degeneration Orbitrap fusion 
UnknownBoosting Free-Energy Perturbation Calculations with GPU-Accelerated NAMD.
Not available
S-EPMC7686227 | biostudies-literature
UnknownNeovascular Age-Related Macular Degeneration (nAMD): A Review of Emerging Treatment Options.
Not available
S-EPMC8965014 | biostudies-literature
UnknownParallel Generalized Born Implicit Solvent Calculations with NAMD.
Not available
S-EPMC3222955 | biostudies-literature
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