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TranscriptomicsNanog Independent Reprogramming to iPSCs with Canonical Factors
It has been suggested that the transcription factor Nanog is essential for the establishment of pluripotency during the derivation of embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. However, successful reprogramming to pluripotency with a growing list of divergent transcription f...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-53212 | biostudies-arrayexpress
GenomicsNANOG metabolically reprograms tumor-initiating stem-like cells in oxidative phosphorylation and fatty acid metabolism
Stem cell markers such as NANOG have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. In the present study, we show that Toll-like receptor 4 (TLR4) signaling phosphorylates E2F1 to transactivate NANOG. Down-regulation of ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-68237 | biostudies-arrayexpress
ProteomicsTranslation control by maternal Nanog promotes oocyte maturation and early embryonic development
proteomes of nanog mutant eggs with WT were quantitatively compared using isobaric tags for relative and absolute quantitation (iTRAQ) technology
ORGANISM(S): Danio Rerio 
2022-08-24 | PXD036250 |
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells
This SuperSeries is composed of the following subset Series: GSE34904: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1) GSE34912: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 2) GSE34918: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34921 | biostudies-arrayexpress
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 4)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34920 | biostudies-arrayexpress
TranscriptomicsNANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice1, where its precise role is yet unclear2-4. We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/Act...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71933 | biostudies-arrayexpress
GenomicsNANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers [ChIP-seq]
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice1, where its precise role is yet unclear2-4. We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/Act...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71932 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse germ cells with conditional Nanog knockdown.
Single Cell Microarray
E10.5 genital ridges (TM at E7.5) incubated in 0.5mM EDTA/ PBS for 20 minutes at 37ï¾°C were transferred to 2% BSA/ PBS. PGCs were collected from the genital ridges pierced with fine glass needles. Released PGCs were identified by their morphological characteristics and tr...
ORGANISM(S): Mus musculus 
2009-11-16 | E-MEXP-2411 | biostudies-arrayexpress
TranscriptomicsNanog is Dispensable for the Generation of Induced Pluripotent Stem Cells
Cellular reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) can be achieved through forced expression of the transcription factors Oct4, Klf4, Sox2 and c-Myc (OKSM). These factors, in combination with environmental cues, induce a stable intrinsic pluripotency network that con...
ORGANISM(S): Mus musculus 
2014-01-28 | E-GEOD-53832 | biostudies-arrayexpress
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34904 | biostudies-arrayexpress
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