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ProteomicsIn-depth proteomic analysis of nasal secretions from chronic rhinosinusitis and nasal polyps
Considering the complex and multifarious features of Chronic rhinosinusitis (CRS) including immunologic patterns, novel modalities are needed to reflect clinical and pathophysiological endotypes beyond nasal polyps.We aimed to investigate the proteome of nasal secretions on filter paper from CRS pat...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD013330 | Pride
Nasal secretion Chronic rhinosinusitis Nasal polyps Label-free quantification 
Transcriptomics3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product (nasal epithelial cells-microRNA dataset).
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2018-04-01 | E-MTAB-6613 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of nasal polyp derived human IL17RB positive and negative T-helper cells
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in western countries is characterized by eosinophilia, IgE production and Th2 cytokine expression. Type 2 innate lymphoid cells (ILC2) from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33 although the relevance of this axi...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-70898 | biostudies-arrayexpress
MetabolomicsResearch on the microbiota and metabolic characteristics of type 2 chronic rhinosinusitis based on the analysis of 16S amplicon sequencing combined with metabolomics

Objective:

To investigate the diversity of nasal microbiota and metabolic characteristics of patients with Type 

2 chronic rhinosinusitis, as well as the interactions and potential regulatory relationships between 

the nasal microbiota and their metabolites by conducti...

2025-10-21 | MTBLS13192 | MetaboLights
TranscriptomicsA global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps
Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulati...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-39957 | biostudies-arrayexpress
UnknownA diagnostic model for predicting type 2 nasal polyps using biomarkers in nasal secretion.
Not available
S-EPMC9811186 | biostudies-literature
ProteomicsProteome of nasal epithelial cells infected with Bordetella pertussis B1917
We analyzed the proteomic response of air-liquid interface cultures of primary nasal epithelial cells from healthy subjects 48 hours after infection with B. pertussis B1917 wild type, its delta-bteA mutant which has an in-frame deletion of the bteA gene, and the BteA complemented delta-bteA::bteA st...
ORGANISM(S): Homo sapiens (Human) Bordetella pertussis 
2025-07-22 | PXD060316 | Pride
Human nasal epithelial cell Airway epithelium Air-liquid interface culture Type iii secretion system Btea effector Bordetella pertussis 
TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN NASAL TISSUE CULTURES
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2016-08-31 | E-MTAB-4740 | biostudies-arrayexpress
ClinicalDouble-Blind Randomized Placebo-Controlled Trial on Clinical and Biological Effects of Oral Corticosteroids or Doxycyclin in Patients With Nasal Polyposis
This study is a double-blinded, randomized, placebo controlled, multi-center trial in which 120 subjects with nasal polyposis (NP) will be treated during 20 days with oral corticosteroids (OCS) in decreasing doses or oral doxycyclin (ODOX) or placebo. At each visit the clinical and the biological ac...
2040498 | ecrin-mdr-crc
UnknownIdentification of Inflammatory Endotypes by Clinical Characteristics and Nasal Secretion Biomarkers in Chronic Rhinosinusitis with Nasal Polyps.
Not available
S-EPMC10614570 | biostudies-literature
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