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ProteomicsN-terminal acetylome analysis reveals an expanded substrate profile for the NatC N-terminal acetyltransferase complex in yeast
N-terminal acetylation is a conserved protein modification among eukaryotes, and the yeast Saccharomyces cerevisiae is a valuable model system for studying this modification. The enzymes responsible for the bulk of protein N-terminal acetylation in S. cerevisiae are the N-terminal acetyltransferases...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-26 | PXD039544 | Pride
Natc N-terminal acetylation N-alpha-acetyltransferase 30 (naa30) Saccharomyces cerevisiae N-terminal acetylome N-terminal cofradic N-terminomics. 
UnknownMolecular mechanism of N-terminal acetylation by the ternary NatC complex.
Not available
S-EPMC8500922 | biostudies-literature
ProteomicsImpact of NatC on N-terminal acetylome
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human N-terminal acetylome. Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD034992 | Pride
Lc-ms/ms Hap cells Natc Scx N-terminal enrichment 
UnknownExpanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
Not available
S-EPMC9867985 | biostudies-literature
ProteomicsLFQ shotgun proteomic analysis of HAP1 NatC KO cells
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human proteome (protein abundance). Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034104 | Pride
Hap1 cells Natc ko Lfq Shotgun Lc-ms/ms 
UnknownCharacterization of Evolutionarily Conserved Trypanosoma cruzi NatC and NatA-N-Terminal Acetyltransferase Complexes.
Not available
S-EPMC6431383 | biostudies-literature
UnknownDivergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Not available
S-EPMC7608589 | biostudies-literature
UnknownMolecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Not available
S-EPMC9898148 | biostudies-literature
UnknownThe DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.
Not available
S-EPMC4199503 | biostudies-literature
OtherN-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochem...
ORGANISM(S): Homo sapiens 
2023-09-18 | GSE221447 | GEO
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