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ProteomicsComprehensive proteomic comparison between native tendon and ligament and 3D tissue engineered tendon and ligament constructs
Tendons and ligaments are important biological structures in both humans and animals. They are part of dense connective tissue and are crucial to the functioning of the musculoskeletal system. However, they are commonly damaged due to age-related wear and tear, trauma or sports related incidents, wh...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2016-06-27 | PXD003094 | Pride
3d tissue engineered ligament Native tendon Native ligament 3d tissue engineered tendon 
TranscriptomicsRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Tendon fascicles were analysed directly after isolation from the tail of freshly euthanized mice and after of after ex vivo culture for 6 days. Fascicles were cultured in either serum containing medium (10%) or in serum-free medium at 21% oxygen and 37 degrees celsius.
ORGANISM(S): Mus musculus 
2020-09-15 | E-MTAB-9540 | biostudies-arrayexpress
MetabolomicsGenomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon rel...
2017-07-14 | MTBLS322 | MetaboLights
TranscriptomicsTranscriptomic profiling of chondrocytes and tenocytes in de- and re-differentiation relative to native tissue
De- and re-differentiation represent phenotypic transitions that may contribute to loss of function in ageing musculoskeletal tissues. Applying a systems biology network analysis approach to global gene expression profiles derived from common in vitro culture systems (monolayer and three-dimensiona...
ORGANISM(S): Rattus norvegicus 
2016-06-01 | E-MTAB-4800 | biostudies-arrayexpress
GenomicsRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
RNA sequencing of native and ex vivo cultured murine tail tendon fascicles
PRJEB40339 | ENA
ProteomicsImpact of therapeutic and synchrotron x-rays on collagen I
Biological tissues are exposed to X-rays under controlled conditions in both medical applications (diagnostic imaging and radiotherapy) and research studies (e.g. microcomputed X-ray tomography: microCT). Radiotherapy regimes may deliver doses of up to 50Gy to both the target tumour and to healthy t...
ORGANISM(S): Gallus gallus (Chicken) 
2025-03-11 | PXD050691 | Pride
Collagen Synchrotron imaging Tendon Computed tomography Therapeutic radiation 
ProteomicsHypoxia Induces HIF-1α Activation in Tendon Stem Cells to Enhance Extracellular Vesicle-mediated Tendon Repair
Tendon injuries are challenging to treat due to the limited blood supply and low cell density in tendon tissue. Tendon stem cells (TSCs) typically reside in a hypoxic environment (1%-5% oxygen), which may be crucial for their physiological function. In this study, we demonstrated that under hypoxic ...
ORGANISM(S): Rattus Norvegicus 
2025-06-20 | PXD065303 |
GenomicsHypoxia-inducible factor 1a and Hypoxia in Tendon Fibroblasts
Hypoxia-inducible factor 1a and Hypoxia in Tendon Fibroblasts
PRJNA1456132 | ENA
UnknownProteomic differences between native and tissue-engineered tendon and ligament.
Not available
S-EPMC5132062 | biostudies-literature
TranscriptomicsHypoxia-inducible factor 1a and Hypoxia in Tendon Fibroblasts
Tendons are soft, connective tissues that are essential for joint stability and mobility. Tendons are susceptible to injury, such as rupture and tendinopathy, and limited therapeutic strategies are available to restore native structure and function. The inability to restore adult tendon function is ...
ORGANISM(S): Mus musculus 
2026-05-31 | GSE328685 | GEO
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