Natural killer cell

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Unknown (8739)
Transcriptomics (1627)
Genomics (1495)
Proteomics (124)
Other (46)
Methylation profiling (29)
Models (15)
Clinical (15)
Metabolomics (10)
Genomic (1)
Multiomics (1)

Organisms

Homo sapiens (1142)
Mus musculus (742)
Rattus norvegicus (27)
Arabidopsis thaliana (16)
Bos taurus (15)
Staphylococcus aureus (11)
Danio rerio (8)
Saccharomyces cerevisiae (7)
Sus scrofa (7)
Gallus gallus (6)
Canis lupus familiaris (5)
Mus (4)
Schmidtea mediterranea (3)
Plasmodium falciparum (3)
Laccaria bicolor (2)
Ascaris suum (2)
Actinobacillus pleuropneumoniae serovar 1 str. 4074 (2)
Shigella flexneri (2)
Pseudomonas syringae pv. tomato str. DC3000 (2)
Aspergillus fumigatus (2)
Helicobacter pylori (2)
Triticum aestivum (2)
Actinobacillus pleuropneumoniae serovar 3 str. JL03 (1)
Pseudomonas fluorescens Pf29Arp (1)
Gorgonia ventalina (1)
Sitodiplosis mosellana (1)
Solea solea (1)
Cucumis sativus var. sativus (1)
Tigriopus californicus (1)
Larix kaempferi (1)

Organisms

Homo sapiens (535)
Mus musculus (404)
Macaca mulatta (10)
Rattus norvegicus (6)
Bos grunniens (5)
Macaca fascicularis (5)
Sus scrofa (4)
Danio rerio (4)
Bos taurus (4)
Plasmodium falciparum (3)
Equus caballus (2)
Salmo salar (2)
feces metagenome (2)
Capra hircus (2)
unidentified (2)
Perameles nasuta (1)
Anguilla anguilla (1)
Papio papio (1)
Homo sapiens/Mus musculus xenograft (1)
human gammaherpesvirus 4 (1)
Poecilia reticulata (1)
Micropterus salmoides (1)
Chlorocebus sabaeus (1)
Mus (1)
Caenorhabditis elegans (1)
Ovis aries (1)
Canis lupus familiaris (1)
Mus musculus domesticus (1)
Gallus gallus (1)

Repository

ENA (1147)
geo (1104)
biostudies-arrayexpress (864)
EGA (83)
pride (67)
MassIVE (25)
iProX (18)
BioModels (12)
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jPOST (6)
PanoramaPublic (4)
Cell Collective (3)
ExpressionAtlas (2)
GPMDB (2)
dbGaP (1)
PAXDB (1)

Tissue

Natural killer cell (20)
Blood (17)
Cell culture (15)
Lung (7)
Liver (7)
Monocyte (6)
B cell (6)
Colon (4)
Kidney (4)
Blood cell (4)
Fibroblast (4)
Gall bladder (3)
Esophagus (3)
Ovary (3)
Adrenal gland (3)
Brain (3)
Heart (3)
Gut (1)
Retina (1)
Placenta (1)
CD8-positive T cell (1)
Rectum (1)
CD4-positive T cell (1)
Platelet (1)
Spinal cord (1)
Pancreas (1)
Frontal cortex (1)
Urinary bladder (1)
Prostate gland (1)
Testis (1)

Disease

Normal (9)
Colorectal Neoplasms (7)
Breast cancer (2)
Neoplasms (2)
Colon cancer (2)
Cancer (1)
Pulmonary arterial hypertension (1)
Cytomegalovirus seropositive (1)
Ewing family tumor (1)
Embryonal Carcinoma (1)
Aggressive insulitis (1)
Unspecified peripheral T-cell lymphoma (1)
Extranodal NK/T-Cell Lymphoma derived cell line (1)
Burkitt's lymphoma (1)
Untreated prostate cancer (1)
Rheumatoid arthritis (1)
Peripheral T-cell Lymphoma (1)
Chronic active EB virus infection (1)
Extranodal NK/T cell lymphoma, nasal type (1)
Colorectal adenocarcinoma (1)
Prostate cancer (1)
SINV infection (1)
Prostate carcinoma (1)
Nodal peripheral T-cell Lymphoma (1)
Ischemic stroke NOS (1)
Leukemia, Myeloid (1)
Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
Mycoses (1)
Carcinoma, Hepatocellular (1)
Lymphoma (1)

Technology Type

Mass Spectrometry (67)
Shotgun proteomics (33)
Bottom-up proteomics (13)
Data-independent acquisition (8)
Affinity purification coupled with mass spectrometry proteomics (7)
Data-dependent acquisition (7)
Mass spectrometry (6)
Gel-based experiment (4)
Top-down proteomics (4)
Illumina HiSeq 2000 (2)
NMR spectroscopy (2)
Mass spectrometry assay (2)
Immunopeptidomics (2)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II (1)
DiaPASEF (1)
Mass spectrometry imaging (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (39)
Illumina HiSeq 2000 (16)
Illumina HiSeq 2500 (13)
NextSeq 550 (11)
Illumina HiSeq 4000 (9)
NextSeq 500 (9)
Illumina NovaSeq X (8)
NextSeq 2000 (7)
Illumina HiSeq 1000 (3)
Novogene in-house automated library preparation system (2)
Agilent Bioanalyzer (2)
BAS-5000 [FUJIFILM] (2)
Illumina HiSeq 1500 (2)
CellRanger v2.1.0 (1)
10X Genomics Single Cell, V3.1 (1)
KAPA EvoPrep Kit (1)
Novogene automated library prep system (1)
Qiagen RNA extraction kit (1)
ProFlex PCR system (1)
Element AVITI (1)
10X Chromium Controller (1)
10x Genomics Chromium (1)
HiSeq 1500 (1)
BD FACSAria III (1)
Not applicable (1)
Illumina BeadArray reader (1)
Centrifuge (1)
GeneChip Scanner 3000 7G (1)
BD FACSAria III cell sorter (1)
GenePix 4000A [Axon Instruments] (1)

Publication Date

2025 (211)
2026 (194)
2024 (169)
2022 (158)
2023 (145)
2021 (143)
2012 (126)
2014 (106)
2013 (100)
2015 (97)
2016 (93)
2011 (93)
2010 (89)
2018 (65)
2020 (60)
2008 (60)
2019 (59)
2009 (59)
2007 (33)
2017 (30)
2005 (7)
2006 (3)
2004 (1)

UNIPROT ID/AC

C4NUM1 (1)
A2RSY7 (1)
Q0GK43 (1)
Q9ES17 (1)
1433B_MOUSE (1)
1433E_MOUSE (1)
1433F_MOUSE (1)
1433G_MOUSE (1)
1433S_MOUSE (1)
1433T_MOUSE (1)
1433Z_MOUSE (1)
2A5A_MOUSE (1)
2A5E_MOUSE (1)
2A5G_MOUSE (1)
2AAA_MOUSE (1)
2AAB_MOUSE (1)
2ABA_MOUSE (1)
2ABD_MOUSE (1)
3BP1_MOUSE (1)
3BP2_MOUSE (1)
3BP5L_MOUSE (1)
3HAO_MOUSE (1)
3HIDH_MOUSE (1)
3MG_MOUSE (1)
41_MOUSE (1)
4EBP1_MOUSE (1)
4EBP2_MOUSE (1)
4ET_MOUSE (1)
4F2_MOUSE (1)
5NT3A_MOUSE (1)

CHEBI ID

CHEBI:27266 (4)
CHEBI:25017 (3)
CHEBI:28260 (2)
CHEBI:33942 (2)
CHEBI:26271 (2)
CHEBI:18237 (2)
CHEBI:22660 (2)
CHEBI:17234 (2)
CHEBI:28300 (2)
CHEBI:37084 (2)
CHEBI:24898 (2)
CHEBI:15428 (2)
CHEBI:17268 (2)
CHEBI:6650 (2)
CHEBI:28044 (2)
CHEBI:15940 (2)
CHEBI:16449 (2)
CHEBI:30768 (2)
CHEBI:32816 (2)
CHEBI:78320 (2)
CHEBI:27897 (2)
CHEBI:28748 (1)
CHEBI: 4828 (1)
CHEBI: 16086 (1)
CHEBI: 16768 (1)
CHEBI: 29042 (1)
CHEBI: 16218 (1)
CHEBI: 616988 (1)
CHEBI: 88003 (1)
CHEBI: 14314 (1)

Metabolite Name

Leucine (4)
Valine (4)
Ribitol (2)
Glutamate (2)
Galactose (2)
Glycine (2)
Gluconic acid (2)
Taurine (2)
Ribose (2)
Proline (2)
Phenylalanine (2)
Isoleucine (2)
Glutamine (2)
Glucose (2)
Creatine (2)
Tryptophan (2)
Hypoxanthine (2)
(S)-3-methyl-2-oxovaleric acid (1)
Lipids in VLDL and LDL (1)
1h-indole-2,3-dione (1)
Mycothione (1)
Α-D-glucose-1-phosphate (1)
Β-D-glucose-1-phosphate (1)
Mannose phosphate (1)
4-aminobutanoic acid (1)
DL-Sulforaphane (1)
Mephedrone (1)
Tryptophol (1)
Alpha-Camphorene (1)
(plusmn)-Furaneol (1)

First Public Date

2025 (192)
2026 (158)
2024 (153)
2023 (145)
2022 (99)
2021 (91)
2014 (78)
2020 (64)
2019 (48)
2018 (43)
2017 (25)
2015 (25)
2016 (22)
2013 (4)

Modelling Approach

Ordinary differential equation model (12)

Study status

Recruiting (5)
Completed (5)
Terminated (3)
Not provided (2)

Lab affiliation

Cellzome (6)
Departments of Chemical and Biological Engineering, Chemistry, and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States (3)
1. St. Anna Children’s Cancer Research Institute (CCRI), Vienna, Austria 2. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria 3. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria 4. Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria 5. St. Anna Children’s Hospital, Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria (1)
BK21 Plus KNU Multi-Omics based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Republic of Korea (1)
Baylor College of Medicine Radiation Oncology (1)
Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany (1)
Biomolecular Mass Spectrometry and Proteomics, Utrecht University (1)
Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY (1)
Cambridge Institute for Medical Research, University of Cambridge (1)
Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK (1)
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS) (1)
Centre Hospitalier Universitaire Vaudois, Service de Médecine Interne, BH 10-667, Rue du Bugnon 46, CH-1011 Lausanne (1)
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid. (1)
Chief Scientific Officer oNKo-innate Pty Ltd Laboratory Head, Huntington Laboratory Monash Biomedicine Discovery Institute Monash University Victoria Australia (1)
Core Facilities, Istituto Giannina Gaslini, Genoa, Italy (1)
Core Unit Proteomics, Berlin Institute of Health at Charite - Universitaetsmedizin Berlin and Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany (1)
Core facilities National Institute of Health Viale Regina Elena 299 00161 Rome Italy (1)
Department of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, University of Córdoba, International Excellence Agrifood Campus ‘CeiA3’, 14014 Córdoba, Spain (1)
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia (1)
Department of Biochemistry, Western University, Canada (1)
Department of Immunotechnology, Lund University (1)
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Sweden. (1)
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA (1)
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands (1)
Department of Molecular Biology, Princeton University, US (1)
Department of Pathology, Microbiology, and Immunology Vanderbilt University School of Medicine Nashville, TN 37232 USA (1)
Department of Pathology, Saint Louis University, St. Louis, Missouri, United States (1)
Department of Pathology, School of Medicine, Saint Louis University, United States, St. Louis VA Medical Center(VHA), United States (1)
Department of Rheumatology, First Affiliated Hospital of Guangzhou University of Chinese Medicine,China (1)
Department of Science, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy (1)

Keyword

Adult nasal type extranodal NK/T-cell lymphoma (3)
Small intestine lymphoma (3)
Recurrent adult lymphoblastic lymphoma (3)
Recurrent cutaneous T-cell non-Hodgkin lymphoma (3)
Recurrent mycosis fungoides/Sezary syndrome (3)
Recurrent adult T-cell leukemia/lymphoma (3)
Anaplastic large cell lymphoma (3)
Natural killer cell activity (2)
Noncutaneous extranodal lymphoma (2)
Stage IA mycosis fungoides/Sezary syndrome (2)
Stage IB mycosis fungoides/Sezary syndrome (2)
Stage IIA mycosis fungoides/Sezary syndrome (2)
Stage IIB mycosis fungoides/Sezary syndrome (2)
Stage IIIA mycosis fungoides/Sezary syndrome (2)
Stage IIIB mycosis fungoides/Sezary syndrome (2)
Stage IVA mycosis fungoides/Sezary syndrome (2)
Stage IVB mycosis fungoides/Sezary syndrome (2)
Testicular lymphoma (2)
Cutaneous B-cell non-Hodgkin lymphoma (2)
Peripheral T-cell lymphoma (2)
Adult grade III lymphomatoid granulomatosis (2)
Stage I adult Hodgkin lymphoma (2)
Noncontiguous stage II adult Burkitt lymphoma (2)
Noncontiguous stage II adult diffuse large cell lymphoma (2)
Noncontiguous stage II adult diffuse mixed cell lymphoma (2)
Noncontiguous stage II adult diffuse small cleaved cell lymphoma (2)
Noncontiguous stage II adult immunoblastic large cell lymphoma (2)
Noncontiguous stage II adult lymphoblastic lymphoma (2)
Noncontiguous stage II grade 1 follicular lymphoma (2)
Noncontiguous stage II grade 2 follicular lymphoma (2)

IsPrivate

False (12)

Submitter Keywords

Immuno-oncology (7)

Classification

protozoa (3)
viruses (1)

Modification

144.102062 (1)
15.994915 (1)
2x(15)N labeled L-lysine (1)
45.987721 (1)
4x(15)N labeled L-arginine (1)
Not available (1)

Study type

Transcription profiling by array (569)
RNA-seq of coding RNA (104)
ChIP-seq (37)
RNA-seq of coding RNA from single cells (36)
Comparative genomic hybridization by array (15)
CUT&RUN (15)
Methylation profiling by array (14)
RNA-seq of non coding RNA (8)
Other (7)
Unknown experiment type (6)
DNA-seq (6)
RNA-seq of total RNA (6)
ChIP-chip by tiling array (4)
Animal - High-throughput sequencing (4)
ChIP-chip by array (4)
Methylation profiling by high throughput sequencing (4)
Transcription profiling by RT-PCR (3)
MicroRNA profiling by array (3)
Baseline (2)
Transcription profiling by tiling array (2)
Proteomic profiling by array (2)
Transcription profiling by SAGE (1)
Cell line - Two-color microarray (1)
Animal - One-color microarray (1)
Animal - Single-cell sequencing (1)
Translation profiling (1)
Cell line - High-throughput sequencing (1)
RNAi profiling by array (1)
Spatial transcriptomics by high-throughput sequencing (1)
Bisulfite-seq (1)

Release Date

2022 (1058)
2021 (969)
2023 (928)
2025 (913)
2024 (900)
2020 (717)
2019 (535)
2018 (501)
2016 (450)
2017 (430)
2015 (348)
2014 (327)
2013 (258)
2012 (258)
2011 (204)
2010 (179)
2009 (137)
2008 (131)
2026 (125)
2007 (75)
2006 (56)
2005 (31)
2002 (13)
2003 (11)
2004 (10)
2000 (10)
1999 (10)
1998 (8)
2001 (7)
1997 (3)

Location

United States (6)
Canada (5)
South Korea (2)
Taiwan (1)
China (1)
Australia (1)

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Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights

Natural Killer Cells from High Grade Serous Ovarian Carcinoma ascites

Natural killer cells were extracted from the peritoneal cells of ascites of high grade serous ovarian carcinoma patients.

ORGANISM(S): Homo sapiens

2024-12-31 | E-MTAB-14053 | biostudies-arrayexpress

Single-cell RNA sequencing and single-cell CRISPR screens of interacting natural killer and blood cancer cells

To profile the cell states of interacting natural killer (NK) cells and blood cancer cells, we cultured 26 different cell lines representing diverse hematologic neoplasms either alone or with NK cells derived from three healthy human donors. After 24 h co-culture, we labeled the cells from each mono...

ORGANISM(S): Homo sapiens

2023-07-24 | E-MTAB-13204 | biostudies-arrayexpress

Transcription profiling of neonatal and adult mouse natural killer cells

Comparing global gene expression of neonatal and adult natural killer cells to determine if differences in gene expression suggest that different developmental pathways during hematopoiesis are followed in the fetal and adult mouse to produce mature natural killer cells.

ORGANISM(S): Mus musculus

2005-10-01 | E-MEXP-354 | biostudies-arrayexpress

miRNA expression profiling of NKTCL (Natural Killer/T-Cell Lymphoma) samples

We performed a comprehensive genome-wide miRNA expression profiling (MEP) of extranodal nasal-type Natural Killer/T-cell lymphoma (NKTL) using formalin fixed paraffin-embedded tissue (FFPE) (n=30) and NK cell lines (n=6) in comparison with normal NK cells, with the objective of understanding the pat...

ORGANISM(S): Homo sapiens

2011-11-23 | E-GEOD-31377 | biostudies-arrayexpress

TOX2 regulates human natural killer cell development by controlling T-BET expression

Thymocyte selection-associated high mobility group box protein family member 2 (TOX2) is a transcription factor belonging to the TOX family that shares a highly conserved high mobility group DNA binding domain with the other TOX members. While TOX1 has been shown to be an essential regulator of T-ce...

ORGANISM(S): Homo sapiens

2014-12-22 | E-GEOD-58589 | biostudies-arrayexpress

Natural Killer cells treated with arachidonic acid, IL-2 and ascites

Natural killer cells were exptracted from PMBCs of healthy donors, exposed to arachidonic acid, Il-2, both, or ascites and their expression changes identified via RNAseq (QuantSeq).

ORGANISM(S): Homo sapiens

2024-12-31 | E-MTAB-13971 | biostudies-arrayexpress

the MS data involved in the article "Nuclear ACAT1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer"

In this study we aim to explore the metabolic enzyme that affects NK cell function in colorectal cancer, and mainly focus on the mechanism how nuclear ACAT1（Mitochondrial acetyl-CoA acetyltransferase）promotes NK cell infiltration and activation

ORGANISM(S): Homo Sapiens

2025-03-18 | PXD061959 |

Experimental Malaria Infection Triggers Early Expansion of Natural Killer Cells - NK cell response

In order to gain a better understanding of gene expression during early malaria infection, we conducted microarray analysis of early blood responses in mice infected with erythrocytic stage Plasmodium chabaudi. Immediately following infection, we observed coordinated and sequential waves of immune ...

ORGANISM(S): Mus musculus

2010-05-19 | E-GEOD-12727 | biostudies-arrayexpress

Next-generation sequencing identifies the natural killer cell microRNA transcriptome

Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g. granzyme B, GzmB) through unclear molecular mechanisms....

ORGANISM(S): Mus musculus

2010-10-01 | E-GEOD-21003 | biostudies-arrayexpress

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