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MetabolomicsThe natural variance of the Arabidopsis floral secondary metabolites
Application of mass spectrometry-based metabolomics enables the detection of genotype-related natural variance in metabolism. Differences in secondary metabolite composition of flowers of 64 Arabidopsis thaliana (Arabidopsis) natural accessions, representing a considerable portion of the natural var...
2018-04-03 | MTBLS528 | MetaboLights
MetabolomicsNavigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis
Natural variation can be extremely useful in unraveling the determinants of phenotypic trait evolution but has rarely been analyzed with unbiased metabolic profiling to understand how its effects are organized at the level of biochemical pathways. Native populations of Nicotiana attenuata, a wild to...
2015-06-15 | MTBLS203 | MetaboLights
MetabolomicsIndustrial by-products as a novel circular source of biocompatible extracellular vesicles

Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. In this study we explore and define the use of food industry byproducts (BP) as a circular...

2022-05-17 | MTBLS2801 | MetaboLights
ProteomicsMultiplexed thiol reactivity profiling for target discovery of electrophilic natural products
Electrophilic groups, such as Michael acceptors, expoxides, are common motifs in natural products (NPs). Electrophilic NPs can act through covalent modification of cysteinyl thiols on functional proteins, and exhibit potent cytotoxicity and anti-inflammatory/cancer activities. Here we describe a new...
ORGANISM(S): Homo sapiens (Human) 
2017-10-12 | PXD007575 | Pride
Mtrp natural products chemoproteomics 
ProteomicsDiazirine photo-immobilisation for target profiling of natural products and co-factors: pulldown data
Finding the targets of natural products is of key importance in both chemical biology and drug discovery, and deconvolution of cofactor interactomes contribute to the functional annotation of the proteome. Identifying the proteins that underlie natural compound activity in phenotypic screens help to...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-10-06 | PXD033292 | Pride
Photo-immobilisation Pulldowns Natural products profiling Natural products targets 
MetabolomicsResolving coral photoacclimation dynamics through coupled photophysiological and metabolomic profiling
Corals continuously adjust to short term variation in light availability on shallow reefs. Long-term light alterations can also occur due to natural and anthropogenic stressors, as well as management interventions such as coral transplantation. Although short term photophysiological responses are re...
2019-04-11 | MTBLS768 | MetaboLights
ProteomicsCovalent Target Identification and Mechanism Interrogation of Anti-Cancer Natural Products
We integrated quantitative proteomics and activity-based protein profiling (ABPP) approach to systematically elucidate the involved pathways and the covalent targets of natural products.
ORGANISM(S): Homo Sapiens 
PXD036046 |
MetabolomicsMetabolomic profiling of Sophora flavescens under different tissue types using LC–MS-based untargeted metabolomics

Sophora flavescens (Kushen) is a traditional medicinal plant widely used in East Asia for its anti-inflammatory, antimicrobial, and antitumor properties. Its pharmacological activities are mainly attributed to diverse secondary metabolites, including alkaloids, flavonoids, and phenolic compounds....

2026-02-03 | MTBLS13830 | MetaboLights
MetabolomicsProcess-integrated engineered resting cells for biocatalytic production of rare natural sugars from sole methanol molecules
The biocatalytic conversion of green methanol, a promising feedstock, into high value-added products is seen as an attractive way to establish sustainable biomanufacturing. Although natural and engineered microorganisms can utilize methanol, efficiently converting C1 carbon into valuable chemicals r...
2026-06-22 | MTBLS14812 | MetaboLights
MetabolomicsMetabolomic profiling of Sophora flavescens under different tissue types using LC–MS-based untargeted metabolomics

Sophora flavescens (Kushen) is a traditional medicinal plant widely used in East Asia for its anti-inflammatory, antimicrobial, and antitumor properties. Its pharmacological activities are mainly attributed to diverse secondary metabolites, including alkaloids, flavonoids, and phenolic compounds....

2026-03-24 | MTBLS13994 | MetaboLights
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