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ProteomicsAutophosphorylation of the CK1 kinase domain regulates enzyme activity and substrate specificity
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe a new mechanism of CK1 regulation conserved from yeast to human – autopho...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-07-20 | PXD026766 | Pride
Casein kinase 1 Ck1 S. pombe Substrate specificity Kinase regulation 
ProteomicsCK1 promotes double-strand break repair in fission yeast
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. The C-termini of these enzymes are thought to inhibit kinase activity by acting as pseudosu...
ORGANISM(S): Schizosaccharomyces pombe 
2025-05-06 | PXD033223 | Pride
Casein kinase 1 Ck1 Kinase substrates S. pombe Kinase regulation 
ProteomicsIron deficiency and recovery in yeast: a quantitative proteomics approach
A model used to study iron deficiency is yeast, Saccharomyces cerevisiae. Here, we used quantitative (phospho)proteomics to explore the early (4h and 6h) and late (12h) response to ID. We showed that metabolic pathways like the Krebs cycle, amino acid and ergosterol biosynthesis were affected by ID....
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-19 | PXD023484 | Pride
Sl-tmt Ubiquitin-proteasome system Iron-sulfur cluster Nutritional deficiency Orbitrap fusion 
ProteomicsVRK1 is required in VRK2-methylated cancers of the nervous system
Collateral lethality occurs when loss of one paralog renders cancer cells dependent on the remaining paralog. Combining genome scale CRISPR/Cas9 screens coupled with RNA-sequencing in over 900 cancer cell lines, we found that cancers of nervous system lineage, including adult and pediatric gliomas a...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD030599 | Pride
Phosphorylation 
UnknownFull-Featured, Real-Time Database Searching Platform Enables Fast and Accurate Multiplexed Quantitative Proteomics.
Not available
S-EPMC7295121 | biostudies-literature
UnknownCharacterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry.
Not available
S-EPMC6993951 | biostudies-literature
ProteomicsSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of proteins selected from ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-08-11 | MSV000090110 | MassIVE
ProteomicsBioplex 3 AP-MS Dataset for Library Construction
The BioPlex (biophysical interactions of ORFeome-based complexes) network is the result of creating thousands of cell lines with each expressing a tagged version of a protein from the ORFeome collection. Immunopurification of the tagged protein and detection of associated proteins by mass spectromet...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-13 | MSV000088555 | MassIVE
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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