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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
MetabolomicsgeoRge: A Computational Tool To Detect the Presence of Stable Isotope Labeling in LC/MS-Based Untargeted Metabolomics
Studying the flow of chemical moieties through the complex set of metabolic reactions that happen in the cell is essential to understanding the alterations in homeostasis that occur in disease. Recently, LC/MS-based untargeted metabolomics and isotopically labeled metabolites have been used to facil...
2015-09-15 | MTBLS213 | MetaboLights
UnknownThe mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors.
Not available
S-EPMC11470253 | biostudies-literature
UnknownClinical manifestations in female carriers of mucopolysaccharidosis type II: a Spanish cross-sectional study.
Not available
S-EPMC3697996 | biostudies-literature
TranscriptomicsGene expression changes induced by MV130 (Bactek®) in human monocytes-derived dendritic cells.
MV130 is a commercially polyvalent bacterial preparation, which has shown to reduce the the rate of respiratory infections in patients suffering from recurrent respiratory tract infections. However, the immunological mechanisms associated to this clinical benefit remain unknown. We wanted to identif...
ORGANISM(S): Homo sapiens 
2017-12-14 | E-MTAB-5259 | biostudies-arrayexpress
UnknownProtective Role of Nrf2 in Renal Disease.
Not available
S-EPMC7824104 | biostudies-literature
UnknownDesigning a Person-Centred Integrated Care Programme for People with Complex Chronic Conditions: A Case Study from Catalonia.
Not available
S-EPMC8622001 | biostudies-literature
UnknownA fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins.
Not available
S-EPMC3213398 | biostudies-literature
UnknownUnraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA.
Not available
S-EPMC6395343 | biostudies-literature
UnknownNa+ controls hypoxic signalling by the mitochondrial respiratory chain.
Not available
S-EPMC7992277 | biostudies-literature
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