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ProteomicsPhosphorylation of the NBDY microprotein promotes dissociation of biomolecular condensates
Proteogenomic identification of translated small open reading frames in human has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been shown to be essential for cell growth and prolifera...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD026098 | Pride
Phosphorylation Cell cycle Egf Nbdy 
UnknownThe NBDY Microprotein Regulates Cellular RNA Decapping.
Not available
S-EPMC7682656 | biostudies-literature
GenomicsRibosomal profiling of WT and mORF4/NBDY KO hearts
Ribosomal profiling of WT and mORF4/NBDY KO hearts
PRJNA647908 | ENA
GenomicsRibosomal profiling of WT and mORF4/NBDY KO hearts [WT_vs_mORF4-NBDYKO_RNAseq]
Ribosomal profiling of WT and mORF4/NBDY KO hearts [WT_vs_mORF4-NBDYKO_RNAseq]
PRJNA648762 | ENA
GenomicsGlobal RNA stability profiling in human NBDY knockout using TimeLapse-seq
Global RNA stability profiling in human NBDY knockout using TimeLapse-seq
PRJNA607951 | ENA
UnknownATP Acts as a Hydrotrope to Regulate the Phase Separation of NBDY Clusters.
Not available
S-EPMC10523361 | biostudies-literature
TranscriptomicsGlobal RNA stability profiling in human NBDY knockout using TimeLapse-seq
We previously identified a conserved human microprotein NoBody/NBDY that can interact with the mRNA decapping complex through EDC4 and affects the expression of an NMD (nonsense-mediated decay) substrate. However, it remains unclear the exact mechanism of NBDY-regulated RNA stability change and whet...
ORGANISM(S): Homo sapiens 
2020-12-16 | GSE145682 | GEO
TranscriptomicsRibosomal profiling of WT and mORF4/NBDY KO hearts [WT_vs_mORF4-NBDYKO_RNAseq]
Left ventricles from the hearts of adult WT and mORR4/NBDY KO mice were obtained.
ORGANISM(S): Mus musculus 
2020-07-27 | GSE155133 | GEO
TranscriptomicsRibosomal profiling of WT and mORF4/NBDY KO hearts
Left ventricles from the hearts of adult WT and mORR4/NBDY KO mice were obtained. Per heart, RNA-sequencing and ribosomal profiling was performed on the same heart
ORGANISM(S): Mus musculus 
2020-07-23 | GSE154940 | GEO
OtherGlobal RNA stability profiling in HEK293T cells under EGF treatment using TimeLapse-seq
We discovered through LC-MS/MS followed by biochemical assays and immunofluorescence that human microprotein NoBody/NBDY can be phosphorylated during EGF signaling transduction, and that this single post-translational modification of the smallest decapping complex component known to date is necessar...
ORGANISM(S): Homo sapiens 
2021-12-31 | GSE146213 | GEO
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