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Hsa-mir-365-2 is one of the two precursors that give rise to miR-365. We discovered that miR-365 directly regulates a lung cancer and developmental gene termed thyroid transcription factor 1 (TTF-1 or NKX2-1). Hsa-mir-365-2 was transfected into NCI-H441 cells via retrovirus-mediated gene transfer. A...
ORGANISM(S): Homo sapiens 
Low serum levels or deficiency of 1α,25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or acute respiratory distress syndrome, although the molecular mechanisms behind this observation are not yet understood. VD3 is known to stimulate lung maturity, a...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040622 | Pride
Transcriptomic profiling of NCI-H441 epithelial cells following BCG exposure in a human cell-line lung-on-chip model
RNA-seq transcriptome analysis in NCI-H209 and NCI-H441 cells transfected with TTF-1/NKX2-1 or ASCL1 siRNAs.
This study investigated early transcriptional responses of NCI-H441 lung epithelial cells in a human cell-line lung-on-chip (CLLOC) model following epithelial-side exposure to Bacillus Calmette-Guérin (BCG). The CLLOC model contained NCI-H441 epithelial cells in the epithelial compartment and human ...
ORGANISM(S): Homo sapiens 
2026-09-30 | GSE344004 | GEO
TTF-1/NKX2-1 and ASCL1 binding regions in NCI-H209 and NKX2-1 binding regions in NCI-H441, replicate 2
Hsa-mir-365-2 is one of the two precursors that give rise to miR-365. We discovered that miR-365 directly regulates a lung cancer and developmental gene termed thyroid transcription factor 1 (TTF-1 or NKX2-1). Hsa-mir-365-2 was transfected into NCI-H441 cells via retrovirus-mediated gene transfer. A...
ORGANISM(S): Homo sapiens 
2011-11-15 | GSE33672 | GEO
Transcriptome analysis of TNFα or necroptosis-induced stimulation in the NCI-H441 cell line with RIPK3 knocked down by siRNA.
We aimed to elucidate the role of RIPK3 in lung adenocarcinoma by analyzing expression variations through RNA sequencing. To achieve this, we suppressed the expression of RIPK3 in the NCI-H441 lung adenocarcinoma cell line, which highly expresses this gene, using multiple siRNAs. We then subjected t...
ORGANISM(S): Homo sapiens 
2026-04-01 | GSE270211 | GEO
Expression data of NCI-H441 cells stably expressing hsa-mir-365-2 vs empty vector
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