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ProteomicsShotgun analysis of proteins in NDUFA11 KO and WT HEK 293T cells.
The effect of the depletion of an ETC complex I protein component - NDUFA11 on the proteome in HEK 293T cells was studied. TMT-based relative quantification of protein levels were performed in NDUFA11 KO vs WT cells and in NDUFA11 KO vs WT cells that expressed an EGFP-MAPT (Tau protein) construct. I...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD038397 | Pride
Ndufa11 ko Egfp-mapt expression Etc complex i Hek 293t 
ProteomicsShotgun measurements of proteome fractionations: mitochondria, aggregates, and soluble fraction of NDUFA11 KO and WT HEK293T cells
Perturbed proteostasis and mitochondrial dysfunction are often associated with age-related diseases such as Alzheimer’s and Parkinson’s diseases. However, the link between them remains incompletely understood. Mitochondrial dysfunction causes proteostasis imbalance, and cells respond to restore prot...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD038004 | Pride
Mitochondria Aggregates Tmt Ndufa11 ko 
ProteomicsProtein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress
Perturbed proteostasis and mitochondrial dysfunction are often associated with age-related diseases such as Alzheimer’s and Parkinson’s diseases. However, the link between them remains incompletely understood. Mitochondrial dysfunction causes proteostasis imbalance, and cells respond to restore prot...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD031374 | Pride
Ndufa11 ko Mitochondrial stress response 
ProteomicsProtein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress
Perturbed proteostasis and mitochondrial dysfunction are often associated with age-related diseases such as Alzheimer’s and Parkinson’s diseases. However, the link between them remains incompletely understood. Mitochondrial dysfunction causes proteostasis imbalance, and cells respond to restore prot...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD031282 | Pride
Human cells Protein homeostasis Stress response Mitochondrial dysfunction Protein aggregation Quantitative proteomics 
TranscriptomicsAn increase in the abundance of Tim23 in Arabidopsis thaliana results in the disruption of complex I and activation of mitochondrial biogenesis.
Analysis of changes in global transcript abundance profiles of 2 week old tim23 OE (overexpressor) and tim23 KO (knock-out) mutant Arabidopsis plants complared to wild-type (Col-0) using Affymetrix GeneChipﾙ Arabidopsis ATH1 Genome Arrays.
ORGANISM(S): Arabidopsis thaliana 
2011-09-01 | E-MEXP-3309 | biostudies-arrayexpress
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