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ProteomicsThe pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD017508 | Pride
Sirtuins Leukemia Human Mitochondria Orbitrap q-exactive 
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
TranscriptomicsChondrosarcoma cells: sphere vs adherent
Transcriptional profiling of human chondrosarcoma sphere vs adherent cells Two different growth conditions, sphere vs adherent
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-47823 | biostudies-arrayexpress
TranscriptomicsAssessment of low-dose BPA toxicity in thyroid follicular cells by gene expression microarray.
Gene expression microarrays were performed to investigate the molecular effects of exposure to BPA on thyrocytes (FRTL-5). Cells were treated with low-lose BPA (10^-9 M) at different time points to analyse time dependent toxicity.
ORGANISM(S): Rattus norvegicus 
2016-02-29 | E-MTAB-4458 | biostudies-arrayexpress
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