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MetabolomicsRcrR: A Multifunctional Transcriptional Regulator Orchestrating the cariogenic virulence of Streptococcus mutans

We systematically investigated RcrR's contribution to cariogenic virulence using isogenic wild-type, DeltarcrR deletion mutant, and complemented strains. We assessed bacterial growth, biofilm architecture, acid tolerance, and H+-ATPase activity. To delineate the global regulatory network, we inte...

2026-08-06 | MTBLS15272 | MetaboLights
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
MetabolomicsDual RNA regulator VcdRP in V. cholerae modulates central metabolism
Not available
ORGANISM(S): Vibrio cholerae 
ST001752 | MetabolomicsWorkbench
TranscriptomicsHMGA1: A master regulator of tumor progression in triple-negative breast cancer cells
Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process are poorly understood. Here, we show for the first time that the high mobility group A1 (HMGA1) gene drives metastatic progression in triple ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-45483 | biostudies-arrayexpress
MetabolomicsMulti-omics Analysis Reveals Multiple Metabolic Processes, Phytohormone Signaling, and the Negative Regulatory Role of ZmPP2CA11 in Maize Seedling Water-Deficit Responses

In this study, the physiological phenotyping, RNA sequencing, widely targeted metabolomics, and phytohormone profiling were used to examine the responses of maize seedlings to progressive PEG-induced osmotic stress and their recovery after PEG removal. 

2026-09-26 | MTBLS15230 | MetaboLights
MetabolomicsMetabolomic study of Escherichia coli K-12 MG1655 WT and its transcriptional regulator mutants under anaerobic fermentation conditions
Not available
ORGANISM(S): Escherichia coli 
ST001421 | MetabolomicsWorkbench
MetabolomicsMetabolomic study of Escherichia coli K-12 MG1655 WT and its transcriptional regulator double mutants under anaerobic fermentation conditions
Not available
ORGANISM(S): Escherichia coli 
ST002076 | MetabolomicsWorkbench
TranscriptomicsThe cytokinin type-B response regulator PtRR13 is a negative regulator of adventitious root development in Populus
Adventitious root formation at the base of plant cuttings is an innate de novo organogenesis process that allows massive vegetative propagation of many economically and ecologically important species. The early molecular events following shoot excision are not well understood. Using whole-genome mic...
ORGANISM(S): Populus tremula x Populus alba 
2010-06-21 | E-GEOD-15049 | biostudies-arrayexpress
TranscriptomicsThe Candida glabrata transcription factor Stb5p is a negative regulator of ATP-binding cassette transporters
The opportunistic yeast pathogen Candida glabrata is recognized for its ability to acquire resistance during prolonged treatment with azole antifungals. Resistance to azoles is largely mediated by the transcription factor PDR1, resulting in the upregulation of ATP-binding cassette (ABC) transporter ...
ORGANISM(S): Candida glabrata 
2013-03-11 | E-GEOD-37071 | biostudies-arrayexpress
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