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ProteomicsCharacterization of NEK10 proteomic interactions under genotoxic stress
Genetic studies in Aspergillus nidulans identified a family of protein kinases (NIMA- Never in mitosis gene A) crucial for cell cycle progression in fungus. Highly conserved in mammals, various members of NEKs (Nima-related kinases) cross-function in signaling networks depicted in at least one of th...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD018294 | Pride
Mitochondria Immunoprecipitation Nek10 Lc-ms/ms 
ProteomicsHuman NEK10 knockout airway ALI Fe-IMAC-MSMS
We identified inactivating mutations in NEK10, a poorly characterized human protein kinase, in a novel human bronchiectasis syndrome. In order to understand effects of loss of its function on the airway phosphoproteome, NEK10 was CRISPR/Cas9 targeted in human airway air-liquid interface (ALI) cultu...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016600 | Pride
Human Nek10 Phosphoproteomics Airway 
UnknownNEK10 interactome and depletion reveal new roles in mitochondria.
Not available
S-EPMC7189645 | biostudies-literature
UnknownNEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status.
Not available
S-EPMC11460017 | biostudies-literature
Unknownβ-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.
Not available
S-EPMC11087748 | biostudies-literature
UnknownA human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
Not available
S-EPMC7018620 | biostudies-literature
UnknownMutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Not available
S-EPMC7592914 | biostudies-literature
GenomicsCYTOGENETIC AND TRANSCRIPTOME PROFILING ANALYSIS OF MATCHED IN SITU/INVASIVE CUTANEOUS SQUAMOUS CELL CARCINOMAS FROM IMMUNOCOMPETENT PATIENTS [CytoScanHD_Array]
Although most cutaneous squamous cell carcinomas (cSCC) develop from actinic keratoses (AK), the key events for this evolution remain unclear. We have combined the results of different genomic and expression array platforms on matched samples of sun-exposed skin, AK and cSCC from ten immunocompetent...
ORGANISM(S): Homo sapiens 
2019-01-03 | GSE108009 | GEO
TranscriptomicsCYTOGENETIC AND TRANSCRIPTOME PROFILING ANALYSIS OF MATCHED IN SITU/INVASIVE CUTANEOUS SQUAMOUS CELL CARCINOMAS FROM IMMUNOCOMPETENT PATIENTS [HuGene-2_0-st]
Although most cutaneous squamous cell carcinomas (cSCC) develop from actinic keratoses (AK), the key events for this evolution remain unclear. We have combined the results of different genomic and expression array platforms on matched samples of sun-exposed skin, AK and cSCC from ten immunocompetent...
ORGANISM(S): Homo sapiens 
2019-01-03 | GSE108008 | GEO
UnknownCounterregulation of cAMP-directed kinase activities controls ciliogenesis.
Not available
S-EPMC5964327 | biostudies-literature
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