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ProteomicsThe genetic and dietary landscape of the muscle insulin signalling network
Using mass spectrometry-based phosphoproteomics, we quantified 23,126 phosphosites in the skeletal muscle of five genetically distinct inbred mouse strains exposed to two controlled dietary environments, with and without acute insulin treatment. Almost half of the insulin-regulated phosphoproteome w...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-21 | PXD041229 | Pride
Phosphoproteomics Glucose regulation Phosphoproteome Diet Environment Genetic Skeletal muscle Mouse 
ProteomicsDeep 3T3-L1 adipocyte proteome at 10 days post-differentiation
Here we conducted a comprehensive analysis of the proteome of the widely used 3T3-L1 murine adipocyte laboratory cell line at 10-days post-differentiation.
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD039532 | Pride
Mouse Adipocytes 
ProteomicsDeep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots
The two major mammalian adipose tissue depots are subcutaneous adipose tissue (SAT), which is associated with metabolic protection, and abdominal/visceral (VAT), which contributes to metabolic disease. To investigate the molecular underpinnings of these differences, we conducted a comprehensive anal...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD039523 | Pride
Mouse Adipocytes Adipose tissue Visceral fat Subcutaneous fat 
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