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ProteomicsEPLIN-Beta is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis. Az1-mediated degradation of...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039865 | Pride
Ubiquitin-independent degradation Antizyme Cell migration Eplin/lima1 
ProteomicsTensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions
The formation of healthy tissue involves continuous remodelling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms remain unclear. Here we examine how tensin3 contribut...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD026343 | Pride
Vinculin Fibronectin Tensin Talin Extracellular matrix 
ProteomicsZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion
ZHX3, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of ZHX3 in the human pancreatic β cell...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD046714 | Pride
Beta cell Type 2 diabetes  zhx3  gluconeogenesis  fasting blood glucose  hepatic glucose production  liver  hepatocytes  uric acid  slc17a1 
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