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MetabolomicsMonocolonization with Bacteroides thetaiotaomicron exerts region-specific effects on Alzheimer’s disease-related traits in the murine brain

Bacteroides thetaiotaomicron (B. theta) dominates the gut microbiome of most mammals. This strictly anaerobic gut symbiont colonizes the mucus layer of host intestinal epithelial cells in both healthy and diseased conditions. Reduced neuronal and vagal afferent innervation observed in ge...

2025-12-15 | MTBLS12896 | MetaboLights
MetabolomicsCorpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains (MS (MTBLS))

Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here we perform MALDI-MSI analysis of glycogen at different chain lengths in patients at different stages of Alzheimer's Disease. We look at frontal c...

2026-06-12 | MTBLS14754 | MetaboLights
TranscriptomicsTranscription profiling of various types of murine cerebellum cells to investigate the pre-neoplastic stage of medulloblastoma
SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2426 | biostudies-arrayexpress
TranscriptomicsIdentification of novel candidate oncogenes in chromosomal region 17p11.2-p12 in human osteosarcoma
in 25% - 30% of all OS cases the chromosome region 17p11.2-p12 is aberrant. Using SNP array in conjunction with expression microarrays we try to identify genes which can be classified as oncogens or are in someway benificial to the survival of the tumor. To identify minimal significant amplified reg...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-32964 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Drosophila neoplastic tumors to identify Ets21C dependent target genes
Expressing constitutive active Ras (RasV12) in combination with loss of function mutations in cell polarity determinants such as scrib, dlg or lgl results in large tumors in Drosophila eye imaginal discs. We found that the transcription factor Ets21C critically affects neoplastic growth of RasV12 dl...
ORGANISM(S): Drosophila melanogaster 
2016-06-27 | E-MTAB-4315 | biostudies-arrayexpress
TranscriptomicsProstate CancerM-bM-^@M-^SAssociated Gene Expression Alterations Determined from Needle Biopsies
To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting i...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-40373 | biostudies-arrayexpress
TranscriptomicsMulti-region copy-number analysis
Intra-tumour heterogeneity (ITH) foster tumour adaptation and hamper the efficiency of personalised medicine approaches. We investigated the extent of ITH within individual clear cell renal cell carcinomas (ccRCC) by multi-region sampling and copy number analysis. We analyzed 63 tumour regions and 8...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-47077 | biostudies-arrayexpress
GenomicsBEAF-32 insulator regulates gene expression of genes involved in cell polarity and neoplastic growth.
This SuperSeries is composed of the following subset Series: GSE36735: Distribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq] GSE36736: Genome wide transcriptional profiling of BEAF-32 in wing imaginal tissues of wildtype and mutants [expresion array] Refe...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36737 | biostudies-arrayexpress
UnknownDifferential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation.
Not available
S-EPMC3168499 | biostudies-literature
TranscriptomicsMolecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy
Patients with high-risk localized prostate cancer (tumor-node-metastasis ≥ T2b or prostate-specific antigen ≥ 15 ng/mL or Gleason glade ≥ 4+3) were enrolled into a phase II clinical trial of neoadjuvant chemotherapy with docetaxel and mitoxantrone followed by prostatectomy. Pretreatment prostate tis...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-40434 | biostudies-arrayexpress
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