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ProteomicsIdentify FOXA2-interacting proteins in NEPC cells
Following extensive treatment with androgen receptor (AR) pathway inhibitors, a significant number of metastatic prostate cancer develop treatment resistance, and approximately 20% of these castration-resistant prostate cancers (CRPC) transdifferentiate, at least partially, into neuroendocrine (NE) ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD061080 | Pride
Nepc Foxa2 
ProteomicsIdentify FOXA2-interacting proteins in NEPC cells
Following extensive treatment with androgen receptor (AR) pathway inhibitors, a significant number of metastatic prostate cancer develop treatment resistance, and approximately 20% of these castration-resistant prostate cancers (CRPC) transdifferentiate, at least partially, into neuroendocrine (NE) ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD061127 | Pride
Nepc Foxa2 
GenomicsLSD1 inhibtion in NEPC cell line models.
LSD1 inhibtion in NEPC cell line models.
PRJNA906527 | ENA
GenomicsSpatial transcriptomics of de novo NEPC and ARPC
Spatial transcriptomics of de novo NEPC and ARPC
PRJNA958184 | ENA
UnknownThe central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC.
Not available
S-EPMC8858611 | biostudies-literature
UnknownKDM4A promotes NEPC progression through regulation of MYC expression.
Not available
S-EPMC12805497 | biostudies-literature
GenomicsKDM4A promotes NEPC progression through regulation of MYC expression [ChIP-seq]
KDM4A promotes NEPC progression through regulation of MYC expression [ChIP-seq]
PRJNA946650 | ENA
GenomicsEZH2 knockout and rescue in WCM154 NEPC organoid model. [RNA-Seq]
EZH2 knockout and rescue in WCM154 NEPC organoid model. [RNA-Seq]
PRJNA1077935 | ENA
GenomicsTargeting serotonin-driven histone serotonylation suppresses lineage plasticity and progression of NEPC
Targeting serotonin-driven histone serotonylation suppresses lineage plasticity and progression of NEPC
PRJNA1254615 | ENA
TranscriptomicsLSD1 inhibtion in NEPC cell line models.
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cancer cell survival, including in prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation. However, a subset of tumors undergoes cellular reprogramming to a more lethal neur...
ORGANISM(S): Homo sapiens 
2023-08-30 | GSE218993 | GEO
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