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UnknownNepenthesin from monkey cups for hydrogen/deuterium exchange mass spectrometry.
Not available
S-EPMC3567866 | biostudies-literature
UnknownThe nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function.
Not available
S-EPMC9478907 | biostudies-literature
UnknownEnzymic and structural characterization of nepenthesin, a unique member of a novel subfamily of aspartic proteinases.
Not available
S-EPMC1133788 | biostudies-literature
UnknownNepenthesin protease activity indicates digestive fluid dynamics in carnivorous nepenthes plants.
Not available
S-EPMC4353617 | biostudies-literature
UnknownBarley Nepenthesin-Like Aspartic Protease HvNEP-1 Degrades Fusarium Phytase, Impairs Toxin Production, and Suppresses the Fungal Growth.
Not available
S-EPMC8358834 | biostudies-literature
ProteomicsCarnivorous plants can decompose the polyesters poly(ethylene terephthalate) and poly(butylene adipate terephthalate)
Plants from the Nepenthes genus, which enumerates approximately 120 species, possess specialized pitchers enabling them to capture and digest various preys, mainly arthropods, from which the plants derive nutrients. The pitcher fluid contains many molecules of noteworthy importance, including antimi...
ORGANISM(S): Nepenthes alata 
2025-08-10 | PXD061907 | Pride
Lc-msms Pitcher Q exactive Nepenthesin Nepenthes 
ProteomicsStructural perturbation at the N-terminal domain of human phosphoglycerate kinase 1 reduces the kinetic stability and unfolding cooperativity of a two-domain enzyme
Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of their features. To investigate how mutations affect hPGK1 foldin...
ORGANISM(S): Homo sapiens (Human) 
2022-11-03 | PXD035628 | Pride
Protein folding  structural perturbation  disease 
ProteomicsPhosphorylation of cytosolic hPGK1 affects protein stability and ligand binding: implications for its subcellular targeting in cancer
Human phosphoglycerate kinase 1 is a key glycolytic enzyme that regulates the balance between ADP and ATP concentrations inside the cell. Phosphorylation of hPGK1 at S203 and S256 has been associated with enzyme import from the cytosol to the mitochondria and the nucleus, respectively. These changes...
ORGANISM(S): Homo sapiens (Human) 
2024-09-07 | PXD049012 | Pride
Protein phosphorylation  protein stability  ligand binding  cancer  phosphoglycerate kinase 
ProteomicsStructural dynamics of Na+ and Ca 1 2+ interactions with full-size mammalian NCX
NCX proteins (Na+/Ca2+ exchangers) are allosterically regulated by cytosolic Ca2+ and Na+ to feedback ion signaling in diverse cell types. The recently discovered cryo-EM structure of the cardiac NCX1.1 provided breakthrough information on the mammalian NCX structure, although the structure-dynamic ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-17 | PXD047098 | Pride
Ncx Membrane proteins Molecule dynamics Mass spectrometry Ion transporters 
ProteomicsTwo pairs of back-to-back α-helices of Kingella kingae RtxA toxin are crucial for the formation of a membrane pore
The RtxA cytotoxin, a member of the RTX (Repeats in ToXin) family of pore-forming toxins, is the primary virulence factor of the paediatric facultative pathogen Kingella kingae. Although structure-function studies of RTX toxins have defined their characteristic domains and features, the exact membra...
ORGANISM(S): Kingella sp. (in: b-proteobacteria) 
2025-02-18 | PXD060913 | Pride
Rtx toxins Kingella kingae 
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