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TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
TranscriptomicsMiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells.
Deficient DNA repair capacity is associated with genetic lesions accumulation and susceptibility to carcinogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate various cellular pathways including DNA repair. Here we hypothesized that the existence of HBV products may interfere with ce...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-27561 | biostudies-arrayexpress
TranscriptomicsGlobal Genome-Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. We measured the distribution of nucleotide excision repair (NER) rates for UV induced lesions throughout the yeast genome. By plotting these repair rates in r...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-21 | E-MTAB-4641 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Csbm/m/Xpa-/- knockout mice to investigate the effect of nucleotide excision repair pathway inactivation
Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria caused by a defect in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csbm/m/Xpa-/- mutants causes a phenotype that reliably mimics th...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-835 | biostudies-arrayexpress
TranscriptomicsRoles for the Transcription Elongation Factor NusA in Both DNA Repair and Damage Tolerance Pathways in Escherichia coli
Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during tran...
ORGANISM(S): Escherichia coli 
2010-07-14 | E-GEOD-22829 | biostudies-arrayexpress
TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
ProteomicsAnd-1 is required for NER repair and promotes skin carcinogenesis
Our project was focused on And-1 regulates NER repair and skin carcinogenesis
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD052800 | Pride
And-1 Ner repair Skin carcinogenesis 
GenomicsThe yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
Background: Repair of DNA damage requires chromatin remodeling to permit removal of the lesions. How nucleosomes are remodelled to initiate repair of DNA damage remains largely unknown. Here, we describe how chromatin is altered during repair of UV-induced DNA damage at the level of the linear organ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-06 | E-MTAB-6569 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung tissue from transcription-coupled repair-deficient (Csb-/-) and wild type mice in response to ozone
We investigated whether transcription-coupled repair deficient mice (Cockayne syndrome B knockout mice (Csb-/-)), known to be sensitive to oxidative stressors, have a different response to ozone than its repair-proficient control, Csb heterozygote (Csb+/-) mice.
ORGANISM(S): Mus musculus 
2006-11-13 | E-TABM-137 | biostudies-arrayexpress
TranscriptomicsMPA and NQO studies (Sevilla)
RNA polymerases deal with obstacles during transcription elongation that need to be removed. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TCR). To improve our knowledge of transcription elongation and its coupling to TCR, we performed DN...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-29 | E-GEOD-11561 | biostudies-arrayexpress
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