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TranscriptomicsTranscription profiling of Mac-1+, c-Kit+ myeloid progenitor cells from mice homozygous for the p42-specific knock-out Cebpa mutation and independently transplanted with leukemic bone marrow, and from control mice heterozygous for Cebpa mutation
5000 Mac-1+, c-Kit+ myeloid progenitor cells from 3 mice homozygous for the p42-specific knockout Cebpa mutation and independently transplanted with leukemic bone marrow, or from 3 control mice heterozygous for Cebpa mutation, were isolated by FACS. Total RNA was extracted and fluorescence labeled f...
ORGANISM(S): Mus musculus 
2008-04-08 | E-MEXP-1444 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse LT-HSC hematopoietic stem cells from wild type and Cebpa knock-in mutant strains
Gene expression of LT-HSC (CD150+Flt3-lin-Sca-Kit+) hematopoietic stem cells from wild type mice was compared with LT-HSC from Cebpa knock-in mutant mice (K/L mutants). Fetal liver cells for each genotype were competitively transplanted into irradiant recipients. Donor-derived LT-HSC cells were iso...
ORGANISM(S): Mus musculus 
2009-11-03 | E-TABM-694 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Cebpa knock-in mutant LSK hematopoietic stem cells
Gene expression of LSK (lin-Sca-Kit+) hematopoietic stem cells from wild type mice was compared with LSK from Cebpa knock-in mutant mice (K/K, K/L, and L/L mutants). Fetal liver cells for each genotype were competitively transplanted into irradiant recipients. Donor-derived LSK cells were isolated b...
ORGANISM(S): Mus musculus 
2009-11-03 | E-TABM-695 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of infiltrating macrophages from injured muscles of Cebpb promoter mutant mice
Gene expression of macrophages from injured muscles of bDCRE mutant mice was compared with that of Cebpb wt mice. Skeletal muscles were injured by cardiotoxin injection and infiltrating macrophages were isolated 6 days post-injury by FACS sorting of Mac-1+F4/80+ cells. 4 biological replicates wer...
ORGANISM(S): Mus musculus 
2009-10-07 | E-TABM-755 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CEBPalpha and CEBPbeta null and/or mutant alleles to investigate epidermal development
Effect of CEBPalpha and CEBPbeta null and/or mutant alleles on epidermal development
ORGANISM(S): Mus musculus 
2009-09-21 | E-MEXP-1719 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Dicer conditional knockout hematopoietic stem cells.
Gene expression of HSC (Lin-Sca-Kit+Flt3-) hematopoietic stem cells from Dicer D/+ mice was compared with LT-HSC from DicerD/D mice. BM cells were noncompetitively transplanted into irradiant recipients, and deletion induced by poly(IC) injection. Donor-derived HSCs were isolated by FACS sorting ...
ORGANISM(S): Mus musculus 
2012-09-21 | E-MTAB-674 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse PreMegE cells from conditional null Fog1 mutants
Gene expression of PreMegE cells from wild type mice was compared with those from conditional null mutants (Fog1 Floxed). Cre excision in mutant mice was induced with polyIC. PreMegE cells were isolated by FACS. Expression profiles of biological replicates were determined by hybridization to Affy...
ORGANISM(S): Mus musculus 
2012-04-08 | E-MTAB-342 | biostudies-arrayexpress
TranscriptomicsThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Gene expression analysis of purified KitL-tomato+ and KitL-tomato- thymic vascular endothelial cells, cortical and medullary thymic epithelial cells from 5 weeks old male kitL-tomato reporter mice Differentially expressed genes analysis of thymic stromal cells
ORGANISM(S): Mus musculus 
2016-01-18 | E-GEOD-62741 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse LSK cells from conditional null Fog1 mutants
Gene expression of LSK cells from wild type mice was compared with those from conditional null mutants (Fog1 Floxed). Cre excision in mutant mice was induced with polyIC. LSK cells were isolated by FACS. Expression profiles of biological replicates were determined by hybridization to Affymetrix M...
ORGANISM(S): Mus musculus 
2011-08-03 | E-MTAB-343 | biostudies-arrayexpress
GenomicsSox4 is a key oncogenic target in C/EBPa mutant Acute Myeloid Leukemia
Mutation or epigenetic silencing of the transcription factor C/EBPa is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-50565 | biostudies-arrayexpress
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