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MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
GenomicsCandida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34260 | biostudies-arrayexpress
TranscriptomicsThe role of HIF-1 in beta-glucan induced response in myeloid cell
beta-glucan induced glycolysis in HIF-1 depedent manner. We reported that beta-glucan injection in mice led to upregulated glycolysis. HIF-1a plays a major role in this process. Mice receives beta-glucan via ip for 4 days. Splenocytes were isolated for RNA sequencing.
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-57206 | biostudies-arrayexpress
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
GenomicsEpigenetic programming during monocyte to macrophage differentiation and trained innate immunity
Monocyte differentiation into macrophages represents one of the cornerstone processes in innate host defense. In addition, immunological imprinting of either tolerance or trained immunity after an initial infection determines the functional fate of innate immune cells and the susceptibility of the h...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-58310 | biostudies-arrayexpress
MetabolomicsUrban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes
Sub-Saharan Africa currently experiences an unprecedented wave of urbanization, which has important consequences for health and disease patterns. This study aimed to investigate and integrate the immune and metabolic consequences of rural or urban lifestyles and the role of nutritional changes assoc...
2021-06-22 | MTBLS2267 | MetaboLights
GenomicsBAMSE Epigene
illumina 450K
EGAD00010001461 | EGA
GenomicsBAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology)
The BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology) study is an ongoing longitudinal, population-based prospective birth cohort including 4,089 children born between 1994 and 1996 in Stockholm, Sweden. The cohort was initially designed to study risk factors for as...
EGAS00001002746 | EGA
GenomicsBAMSE Epigene Data Access Committee
Data Access Committee EGAC00001000786
EGAC00001000786 | EGA
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