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TranscriptomicsGene expression profiling of the effects of Cyclophosphamide on peripheral blood mononuclear cells
Certain anticancer drugs, particularly cyclophosphamide (CTX), were shown to enhance the antitumor efficacy of immunotherapy through different immunomodulatory mechanisms. A better understanding of the cellular and molecular basis of CTX-mediated immunomodulation is needed to improve the efficacy of...
ORGANISM(S): Homo sapiens 
2013-09-02 | E-GEOD-39324 | biostudies-arrayexpress
TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC), HER2 positive, and luminal primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of patients to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1µm for 48 hours. Included are 1 l...
ORGANISM(S): Homo sapiens 
2016-10-01 | E-MTAB-4983 | biostudies-arrayexpress
TranscriptomicsExpression profiling of bronchial epithelium
19 bronchial epithelial SAGE libraries were constructed and analyzed in this study. Discussed in the study: IDENTIFICATION OF NOVEL LUNG GENES IN BRONCHIAL EPITHELIUM BY SERIAL ANALYSIS OF GENE EXPRESSION Kim M. Lonergan1, Raj Chari1, Ronald J. deLeeuw1, Ashleen Shadeo1, Bryan Chi1, Ming-Sound Tsa...
ORGANISM(S): Homo sapiens 
2006-07-14 | E-GEOD-3707 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the brain of Nothobranchius furzeri at different time points
Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group
ORGANISM(S): Nothobranchius furzeri 
2014-07-29 | E-GEOD-52462 | biostudies-arrayexpress
TranscriptomicsThe gain-of-function AKT1E17K allele is oncogenic in mouse mammary gland
The gain-of-function mutation in the pleckstrin homology domain of AKT1 (AKT1E17K) occurs in lung and breast cancer. By use of human cellular models and of a AKT1E17K transgenic Cre-inducible murine strain (R26-AKT1E17K mice) we have demonstrated that AKT1E17K is a bona-fide oncogene for lung epithe...
ORGANISM(S): Mus musculus 
2022-06-01 | E-MTAB-7388 | biostudies-arrayexpress
TranscriptomicsTherapeutic potential of a novel HSP90 Inhibitor, NXD30001, for Neurofibromatosis type 2
Purpose: The growth and survival of NF2-deficient cells are enhanced by the activation of multiple signaling pathways including ErbB2/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The ubiquitously expressed chaperone protein HSP90 is known to be essential for the stabilization of these signaling mol...
ORGANISM(S): Mus musculus 
2013-06-06 | E-GEOD-40187 | biostudies-arrayexpress
TranscriptomicsAnalysis of human myeloma cell lines expressing beta 3 integrin
The aim of these experiments was designed to compare gene expression in human myeloma cell lines expressing beta 3 integrin vs counterpart cell lines that do not express beta 3 integrin. Keywords: Gene expression,cell lines, siRNA Phenotype characterization of both primary and cultured myeloma plas...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-15867 | biostudies-arrayexpress
TranscriptomicsDOCK1 gene derived hsa_circ_0020397 RNA is over-expressed in luminal mammary tumors and it is involved in the epithelial differentiation, growth and motility of the neoplastic cell
Circular-RNAs are an emerging group of regulatory molecules involved in the control of numerous cellular processes and may play a role in the growth and diffusion of various types of tumors. In the present study, we define the expression of 15 selected circular-RNAs, which may be involved in the pr...
ORGANISM(S): Homo sapiens 
2022-06-15 | E-MTAB-10819 | biostudies-arrayexpress
TranscriptomicsDecoding human cytomegalovirus using ribosome profiling
The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like other complex viruses, our understanding of its protein coding potential is far from complete. Here, we use ribosome profiling and transcript analysis to experimentally define the HCMV translation products and follow t...
ORGANISM(S): Human Herpesvirus 5 
2012-10-17 | E-GEOD-41605 | biostudies-arrayexpress
GenomicsTransposable elements and their KRAB-ZFP controllers regulate gene expression in adult tissues
The tetrapod-restricted KRAB-containing zinc finger proteins (KRAB-ZFPs) are essential early embryonic controllers of transposable elements (TEs), which they repress via their cofactor KAP1 and associated effectors through histone and DNA methylation, a process thought to result in irreversible sile...
ORGANISM(S): Mus musculus 
2016-03-15 | E-GEOD-74278 | biostudies-arrayexpress
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