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MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
MetabolomicsMetabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach
Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early...
2023-05-24 | MTBLS1990 | MetaboLights
TranscriptomicsTranscriptome profiles of brain glioma stem cells and normal neural stem cells
A human cDNA microarray comprising 29,187 human genome probes was used to evaluate the transcriptional changes between brian glioma stem cells (GSC) and normal neural stem cells(NSC). There were 6 samples that were analyzed, 3 samples were from glioma stem cells and the other 3 samples form normal n...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-41031 | biostudies-arrayexpress
GenomicsPredictive Biophysical Neural Network Modeling of a Compendium of in vivo Transcription Factor DNA Binding Profiles for Escherichia coli
Predictive Biophysical Neural Network Modeling of a Compendium of in vivo Transcription Factor DNA Binding Profiles for Escherichia coli
PRJNA1118281 | ENA
UnknownBoolean Feedforward Neural Network Modeling of Molecular Regulatory Networks for Cellular State Conversion.
Not available
S-EPMC7736109 | biostudies-literature
TranscriptomicsNatural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-course Transcriptome data.
Time course gene-expression profiling was conducted in human lymphoblastoid cell lines (LUCY) after exposure with 1Gy and 10Gy gamma irradiation. Differentially expressed genes were identified using natural cubic spline regression modeling (NCSRM) and subsequently subjected to gene regulatory networ...
ORGANISM(S): Homo sapiens 
2016-06-11 | E-MTAB-4829 | biostudies-arrayexpress
UnknownModeling Neural Adaptation in Auditory Cortex.
Not available
S-EPMC6133953 | biostudies-literature
UnknownExplainable deep learning for tumor dynamic modeling and overall survival prediction using Neural-ODE.
Not available
S-EPMC10657412 | biostudies-literature
TranscriptomicsDEVELOPMENTAL MicroRNA EXPRESSION PROFILING OF MURINE NEURAL TUBE
BACKGROUND: Development of the neural tube is a highly orchestrated process relying on precise, spatio-temporal expression of numerous genes as well as hierarchies of signal transduction and gene regulatory networks. Disruption of expression of a number of genes participating in these networks is be...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-20879 | biostudies-arrayexpress
TranscriptomicsA quantitative framework to evaluate modeling of cortical development by neural stem cells
In vitro neural stem cell models are widely used to model a wide range of neuropsychiatric conditions. However, how well such models correspond to in vivo brain has not been evaluated in an unbiased, comprehensive manner. We used transcriptomic analyses to compare in vitro systems to developing huma...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-57595 | biostudies-arrayexpress
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