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Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021270 | Pride
Rosette neural stem cells (R-NSCs) represent early stage of neural development and possess full neural differentiation and regionalization capacities. R-NSCs are considered as stem cells of neural lineage and have important implications in study of neurogenesis and cell replacement therapy. However,...
ORGANISM(S): Macaca mulatta 
Definition of genome wide transcriptional enhancers by overlap of p300 and H3K27ac and the role of NFI factors in the regulation of mouse neural stem cells
ORGANISM(S): Mus musculus 
Targeted DamID of embryonic proliferating (epNSCs), quiescent (qNSCs) and larval proliferating neural stem cells (lpNSCs) was performed using worniu-GAL4, tubGAL80ts (for qNSCs and lpNSCs condition) or worniu-GAL4 (for epNSCs condition) as a driver to express nine different Dam-fusions and Dam on it...
ORGANISM(S): Drosophila melanogaster 
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