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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
TranscriptomicsLung cancer
Two prognostically significant subtypes of high-grade lung neuroendocrine tumors independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. BACKGROUND: Classification of high-grade neuroendocrine tumors (HGNT) of the lung currently recognises large-ce...
ORGANISM(S): Homo sapiens 
2004-02-10 | E-GEOD-1037 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human classical midgut carcinoid primary tumors and liver metastasis
We identify genes presenting a specific expression profile in midgut carcinoid cells, primary carcinoids tumors and liver metastasis were gene profiled. Gene expression profiling of classical midgut carcinoid primary tumors and liver metastasis reveal potential novel therapeutic targets and molecula...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-9576 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of lung carcinoma
Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer is not we...
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-56044 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of lung carcinoma : Gene expression data
Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. Experimental Design Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on ...
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-60644 | biostudies-arrayexpress
UnknownNeuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review.
Not available
S-EPMC4665594 | biostudies-literature
GenomicsGene expression data of organoids derived from neuroendocrine carcinomas
Gene expression data of organoids derived from neuroendocrine carcinomas
PRJNA598126 | ENA
ProteomicsUCHL1 is a Molecular Indicator and a Therapeutic Target for Neuroendocrine Carcinomas
Quantitative proteomics analysis was performed on patient derived neuroendocrine tissue xenografts comparing sh control (N=2), and shUCHL1 (N=4), and in NCI-H660 cell line xenografts comparing control (N=3) and LDN-57444 treated (N=3). Each condition was injected in triplicate.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-12-03 | PXD044864 | Pride
Uchl1 Xenografts Prostate cancer Neuroendocrine carcinomas 
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