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TranscriptomicsGenes regulated by UCHL1 in ovarian cancer cells
UCHL1 is related to apoptosis and proliferation in cancers and we sought to identify genes regulated by UCHL1 UCHL1 was knocked down in A2780 (A2780-shUCHL1). A2780-shUCHL1 and A2780-control were cultured in RPMI and total RNA was extracted and hybridizated on Affymetrix.GeneChip.HG-U133_Plus_2
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43884 | biostudies-arrayexpress
ProteomicsPull-Down of UCHL1 from living cells with small molecule probes GK13S, GK13R, and GK16S (1 uM)
UCHL1 was enriched from HEK293 cells (Homo Sapiens) using a probe (PullDown via NeutrAvidin beads). Protein enrichment as a function of substance addition was studied in comparison to a DMSO control.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-01 | MSV000090045 | MassIVE
ProteomicsProteomic analysis of UCHL1 conditional knockout mice
Proteomic analysis of osteoclast precursor cells of UCHL1 conditional knockout mice and wild-type mice was performed
ORGANISM(S): Mus Musculus 
PXD052578 |
ProteomicsDiscovery of a potent and selective covalent inhibitor and activity-based probe for UCHL1, with anti-fibrotic activity
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme (DUB) that is very highly expressed in human brain. UCHL1 has been proposed as a potential therapeutic target in neurodegeneration, cancer, and liver and lung fibrosis, however bona fide molecular functions of UCHL1 are yet...
ORGANISM(S): Homo sapiens (Human) 
2020-11-12 | PXD015825 | Pride
Activity based-probe profiling Human Uchl1 Chemical proteomics Deubiquitination 
GenomicsDifferential gene expression in UCHL1 silenced ovarian cancer cells
Differential gene expression in UCHL1 silenced ovarian cancer cells
PRJNA714628 | ENA
GenomicsUchl1 maintains energy and metabolic homeostatic balance during spermatogenesis
Uchl1 maintains energy and metabolic homeostatic balance during spermatogenesis
PRJNA1111379 | ENA
TranscriptomicsGenes regulated by UCHL1 in ovarian cancer cells
UCHL1 is related to apoptosis and proliferation in cancers and we sought to identify genes regulated by UCHL1
ORGANISM(S): Homo sapiens 
2013-01-30 | GSE43884 | GEO
GenomicsUCHL1 Maintains Microenvironmental Homeostasis of Male Germline Stem Cells by Antagonizing HSPA8
UCHL1 Maintains Microenvironmental Homeostasis of Male Germline Stem Cells by Antagonizing HSPA8
PRJNA993683 | ENA
ProteomicsSmall-Molecule Activity-Based Probe for Monitoring Ubiquitin 2 C‑Terminal Hydrolase (UCHL1) Activity in Live Cells and Zebrafish 3 Embryos
Many reagents have emerged to study the function of specific enzymes in vitro. On the other hand, target specific reagents are scarce or need improvement, allowing investigations of the function of individual enzymes in their native cellular context. Here we report the development of a target-select...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD021557 | Pride
Orbitrap Human 
GenomicsMetabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop
Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop
PRJNA1109283 | ENA
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