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ProteomicsProteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection
Neuromelanin is a complex polymer pigment found primarily in the dopaminergic neurons of human substantia nigra. Neuromelanin pigment is stored in granules including a protein matrix and lipid droplets. Neuromelanin granules are yet only partially characterised regarding their structure and function...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004987 | Pride
Laser microdissection Neuromelanin Substantia nigra Lc-ms/ms 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsThe proteome of neuromelanin granules in dementia with Lewy bodies
Neuromelanin granules (NMGs) are organelle-like structures present in the human substantia nigra pars compacta. Besides neuromelanin, NMGs contain proteins, lipids and metals. As NMG-containing dopaminergic neurons are preferentially lost in Parkinson’s disease and dementia with Lewy bodies (DLB), i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD035310 | Pride
Proteomics Stress granules Substantia nigra pars compacta Dementia with lewy bodies Neurodegeneration Neuromelanin granules 
UnknownNeuromelanin accumulation drives endogenous synucleinopathy in non-human primates.
Not available
S-EPMC10689915 | biostudies-literature
GenomicsDisease duration influences gene expression in neuromelanin-positive cells from Parkinson’s disease patients
Disease duration influences gene expression in neuromelanin-positive cells from Parkinson’s disease patients
PRJNA757020 | ENA
UnknownAbsolute quantification of neuromelanin in formalin-fixed human brains using absorbance spectrophotometry.
Not available
S-EPMC10332574 | biostudies-literature
UnknownBrain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Not available
S-EPMC6405777 | biostudies-literature
UnknownLabel-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy.
Not available
S-EPMC7383895 | biostudies-literature
UnknownProteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection.
Not available
S-EPMC5107900 | biostudies-literature
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