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ProteomicsProteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection
Neuromelanin is a complex polymer pigment found primarily in the dopaminergic neurons of human substantia nigra. Neuromelanin pigment is stored in granules including a protein matrix and lipid droplets. Neuromelanin granules are yet only partially characterised regarding their structure and function...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004987 | Pride
Laser microdissection Neuromelanin Substantia nigra Lc-ms/ms 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsThe proteome of neuromelanin granules in dementia with Lewy bodies
Neuromelanin granules (NMGs) are organelle-like structures present in the human substantia nigra pars compacta. Besides neuromelanin, NMGs contain proteins, lipids and metals. As NMG-containing dopaminergic neurons are preferentially lost in Parkinson’s disease and dementia with Lewy bodies (DLB), i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD035310 | Pride
Proteomics Stress granules Substantia nigra pars compacta Dementia with lewy bodies Neurodegeneration Neuromelanin granules 
UnknownProteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection.
Not available
S-EPMC5107900 | biostudies-literature
UnknownNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes.
Not available
S-EPMC9468065 | biostudies-literature
UnknownCombined enrichment of neuromelanin granules and synaptosomes from human substantia nigra pars compacta tissue for proteomic analysis.
Not available
S-EPMC4083096 | biostudies-literature
UnknownThe Proteome of Neuromelanin Granules in Dementia with Lewy Bodies.
Not available
S-EPMC9688080 | biostudies-literature
UnknownIdentification of L-ferritin in neuromelanin granules of the human substantia nigra: a targeted proteomics approach.
Not available
S-EPMC2722774 | biostudies-literature
ProteomicsA spatially resolved view on the aging substantia nigra: an exploratory proteomic study
Physiological ageing is accompanied by numerous structural and molecular changes in the brain, with varying degrees in different brain areas, and is therefore considered one of the major risk factors for neurodegenerative diseases. As early pathomechanisms of neurodegeneration are often difficult to...
ORGANISM(S): Homo sapiens (Human) 
2025-09-23 | PXD061756 | Pride
Neuromelanin granules Proteomics Parkinson’s disease Aging Dementia with lewy bodies 
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