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ProteomicsEffects of TDP-43 overexpression on neuron proteome and morphology in vitro
Primary neuronal cultures were prepared from transgenic mice overexpressing wildtype human TDP-43 under the control of the prion promoter (hTDP-43Prp).
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD022671 | Pride
Proteomics Tdp-43 Als Ftd Neuron morphology 
UnknownA computational model of motor neuron degeneration.
Not available
S-EPMC4167823 | biostudies-literature
TranscriptomicsAge-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia
Despite the advances in our understanding of aging-associated behavioral decline, we know relatively little about how aging affect neural circuits that underlie specific behaviors. Specifically, we know little about how aging affect expression of genes in specific neural circuits. We have now addres...
ORGANISM(S): Aplysia californica 
2014-02-05 | E-GEOD-46618 | biostudies-arrayexpress
GenomicsTranscriptomic neuron types vary topographically in function and morphology
Transcriptomic neuron types vary topographically in function and morphology
PRJNA1120771 | ENA
TranscriptomicsRNA-seq of mouse astrocytes in monoculture and co-cultured with rat neurons (both inactive and active).
Neurons induce a dramatic transformation in developing astrocytes, causing them to develop a complex stellate morphology resembling their appearance in vivo. However, the transcriptional changes that accompany this transformation are not known, nor are the signalling mechanisms responsible. Similarl...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-MTAB-5514 | biostudies-arrayexpress
ProteomicsNeuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.
Neuron derived exosomes have been enriched from plasma using L1CAM antigen. Vesicles were enriched from plasma of Parkinson Disease patients and controls. The NDE morphology was observed by transmission electron microscope (TEM). miRNA-155 content was studied both in PD-NDE and control-NDE. LC-MS/MS...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020794 | Pride
Proteomics Parkinson disease Neuron derived exosomes Plasma L1cam 
ProteomicsMitochondrial reprogramming using dCas9 boosts glia-to-neuron conversion
Astrocyte-to-neuron conversion has developed into a promising avenue for neuronal replacement therapy. Neurons depend critically on mitochondria function and often die by ferroptosis during the conversion process. Here we examined the extent of adequate mitochondrial reprogramming by morphology and ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-29 | PXD014886 | Pride
Astrocytes Neurons Mitochondria Cas9 
UnknownSNAP: a structure-based neuron morphology reconstruction automatic pruning pipeline.
Not available
S-EPMC10303825 | biostudies-literature
UnknownContrastive learning-driven framework for neuron morphology classification.
Not available
S-EPMC12311092 | biostudies-literature
UnknownNeuron Morphology Influences Axon Initial Segment Plasticity.
Not available
S-EPMC4756267 | biostudies-literature
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