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TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hep3B cells transfected with L1CAM
To compare the transcription profiling between empty vector transfected Hep3B and L1CAM transfected Hep3B
ORGANISM(S): Homo sapiens 
2011-08-01 | E-MEXP-1357 | biostudies-arrayexpress
ProteomicsAnalysis of L1CAM-regulated signaling pathways and cellular responses to anti-L1CAM radioimmunotherapy in human ovarian cancer cells
L1 cell adhesion molecule (L1CAM) is overexpressed in various solid tumors, and its overexpression is linked to increased invasion, metastasis, angiogenesis, cancer stemness, and therapy resistance. However, the mechanisms of L1CAM-mediated carcinogenesis and radioresistance, particularly in high-gr...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD055521 | Pride
Tmt Human ovarian cancer L1cam Phosphoproteomics Radioimmunotherapy 
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD048260 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD048282 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
GenomicsL1CAM promotes human endometrial cancer via NF-κB activation
L1CAM promotes human endometrial cancer via NF-κB activation
PRJNA1273161 | ENA
GenomicsDevelopment of antibody-drug conjugates targeting L1CAM to treat metastatic cancer
Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer
PRJNA1327350 | ENA
GenomicsA Novel Silent Mutation in the L1CAM Gene causing Fetal Hydrocephalus
A Novel Silent Mutation in the L1CAM Gene causing Fetal Hydrocephalus
PRJNA549864 | ENA
TranscriptomicsL1CAM promotes human endometrial cancer via NF-κB activation
RNA-seq analysis of human endometrial carcinoma HHUA cells was performed to determine the impact of L1CAM knockdown. Cells were transduced with shRNA targeting L1CAM or shscramble and harvested 48 hours later for total RNA extraction. This dataset provides insight into gene expression changes associ...
ORGANISM(S): Homo sapiens 
2026-02-02 | GSE299250 | GEO
TranscriptomicsDevelopment of antibody-drug conjugates targeting L1CAM to treat metastatic cancer
Effective treatments for metastatic disease have eluded precision oncology efforts and represent a major unmet need. The L1 cell adhesion molecule (L1CAM) is a transmembrane protein expressed by populations of Metastasis Stem cells (MetSC), that are enriched for the ability to reinitiate and propel ...
ORGANISM(S): Homo sapiens 
2025-12-12 | GSE307811 | GEO
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