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ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD048260 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD048282 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
GenomicsPlacental TRPV2 supports trophoblast function and normal fetal development
Placental TRPV2 supports trophoblast function and normal fetal development
PRJNA1473373 | ENA
Proteomics4D-DIA-based quantitative proteomic analysis reveals the involvement of TRPV2 protein in duck Tembusu virus replication
Using a quantitative proteomics approach based on 4D-DIA combined with LC-MS/MS analysis, we identified TRPV2 as a potential host resistance factor that was significantly upregulated in DF-1 cells 48 hours post-DTMUV infection. Further experiments involving siRNA-mediated knockdown of TRPV2 expressi...
ORGANISM(S): Gallus Gallus 
PXD055452 |
ProteomicsProteome alterations in the human granulosa-like tumor cell line KGN after CRISPR/Cas9-based deletion of TRPV2
Human ovarian granulosa cell tumors (GCT) express the cation channel transient receptor potential vanilloid 2 (TRPV2) to a large percentage (95%), as detected by analyzing a panel of 72 tissue samples. To examine its role, we turned to the GCT-derived cell line KGN. CRISPR/Cas9-based deletion of TRP...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD060778 | Pride
Cannabidiol Granulosa cell tumors Kgn Cell death Trpv2 
GenomicsPlacental TRPV2 supports trophoblast function and normal fetal development [MERSCOPE]
Placental TRPV2 supports trophoblast function and normal fetal development [MERSCOPE]
PRJNA1516568 | ENA
GenomicsAllosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
PRJNA544318 | ENA
TranscriptomicsPlacental TRPV2 supports trophoblast function and normal fetal development
This study investigates the role of the calcium-permeable ion channel TRPV2 in placental development, with a focus on trophoblast differentiation and syncytiotrophoblast lineage specification. Using a conditional knockout mouse model, we demonstrate that loss of Trpv2 leads to placental abnormalitie...
ORGANISM(S): Mus musculus 
2026-08-13 | GSE334003 | GEO
OtherPlacental TRPV2 supports trophoblast function and normal fetal development [MERSCOPE]
While placental functioning arbitrates fetal outcome, the molecular players that underpin normal placental development remain poorly understood. Here, we provide evidence that the Transient Receptor Potential Vanilloid 2 (TRPV2) channel plays an important role in normal placental development, determ...
ORGANISM(S): synthetic construct Mus musculus 
2026-08-28 | GSE344692 | GEO
GenomicsTCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks
TCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks
PRJNA1021654 | ENA
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