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MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of KGN cells

Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted...

2025-04-14 | MTBLS12370 | MetaboLights
ProteomicsMitochondrial dynamics in ovarian granulosa cells during follicular growth and in human KGN cells
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive the growth of follicles. This is, in part, dependent on gonadotropins. Our immunohistochemical studies provided hints of mitochondrial biogenesis and intracellular redistribution in GCs of growing follicles. A cellular mo...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032160 | Pride
Mitochondrial dynamics Ovary Forskolin Camp Kgn Granulosa cells 
ProteomicsThe impact of hypoxia on KGN cells
Human granulosa cells (GCs) give rise to granulosa cell tumors (GCTs), in which a hypoxic situation can be assumed. KGN cells are a widely used cellular model for both tumorous and normal human GCs. In this study, we evaluated consequences of hypoxic (1% O2) versus atmospheric conditions on KGNs for...
ORGANISM(S): Homo sapiens (Human) 
2025-11-19 | PXD056016 | Pride
Proteomics Hypoxia Granulosa cell tumor 
ProteomicsProteome alterations in Filamin A deficient granulosa cell tumor-derived KGN cells.
The goal of the study was to evaluate consequences of Filamin A deficiency in granulosa cell tumor-derived KGN cells. Therefore, proteomes of WT and Filamin A deficient KGN cells were quantitatively compared using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD064136 | Pride
Filamin a Kgn-cells Ovarian cancer Granulosa cells 
GenomicsChIP-seq analysis of G3BP1 in KGN cells
ChIP-seq analysis of G3BP1 in KGN cells
PRJNA1098015 | ENA
ProteomicsProteome alterations in the human granulosa-like tumor cell line KGN after CRISPR/Cas9-based deletion of TRPV2
Human ovarian granulosa cell tumors (GCT) express the cation channel transient receptor potential vanilloid 2 (TRPV2) to a large percentage (95%), as detected by analyzing a panel of 72 tissue samples. To examine its role, we turned to the GCT-derived cell line KGN. CRISPR/Cas9-based deletion of TRP...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD060778 | Pride
Cannabidiol Granulosa cell tumors Kgn Cell death Trpv2 
GenomicsRole of YAP/TAZ in KGN human granulosa cell line
Role of YAP/TAZ in KGN human granulosa cell line
PRJNA838498 | ENA
GenomicsRole of YAP/TAZ in KGN human granulosa cell line [Clariom_S_Human]
Role of YAP/TAZ in KGN human granulosa cell line [Clariom_S_Human]
PRJNA883172 | ENA
TranscriptomicsTranscription profiling of FOXL2 over-expression in human KGN cells
In order to identify novel FOXL2 targets, we have transfected KGN cells using an expression vector containing the coding sequence of FOXL2 or, as a reference, the empty vector (mock transfection). The transcriptome perturbation induced by FOXL2 overexpression was then followed by DNA chips (i.e. FOX...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-MEXP-985 | biostudies-arrayexpress
TranscriptomicsGene knockdown and overexpression of 402C>G FOXL2 in COV434 and KGN cells
Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all GCTs examined. This investigation aims to identify the pat...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-39890 | biostudies-arrayexpress
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