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TranscriptomicsEffects of human skeletal muscle fibroblast and stem cell media on cultured rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Rattus norvegicus 
2026-02-21 | E-MTAB-14399 | biostudies-arrayexpress
GenomicsSpecies-specific progenitor domain extends neurogenesis and increases motor neuron production
Species-specific progenitor domain extends neurogenesis and increases motor neuron production
PRJNA1124941 | ENA
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
TranscriptomicsIsl1-Lhx3 fusion specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs
Combinatorial transcription codes generate the myriad of cell types during development, and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM-complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in e...
ORGANISM(S): Mus musculus 
2012-02-03 | E-GEOD-35510 | biostudies-arrayexpress
UnknownIterative Role of Notch Signaling in Spinal Motor Neuron Diversification.
Not available
S-EPMC4975379 | biostudies-literature
TranscriptomicsHuman skeletal muscle fibroblasts and stem cells cultured with rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Homo sapiens 
2026-02-21 | E-MTAB-14395 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle fibroblasts and stem cells cultured with rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Rattus norvegicus 
2026-02-21 | E-MTAB-14397 | biostudies-arrayexpress
UnknownGDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling.
Not available
S-EPMC3183458 | biostudies-literature
TranscriptomicsIdentification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray
Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Ph...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-9603 | biostudies-arrayexpress
TranscriptomicsAccelerated high-yield generation of limb-innervating motor neurons from human stem cells
Human pluripotent stem cells are a promising source of diverse cells for developmental studies, cell transplantation, disease modeling, and drug testing. However, their widespread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-41795 | biostudies-arrayexpress
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