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ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080847 | MassIVE
TranscriptomicsCritical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.
Abstract
BACKGROUND: Gene expression profiling (GEP) in cells obtained from peripheral blood has demonstrated to be a very useful approach for biomarker discovery and for studying molecular pathogenesis of prevalent diseases. While there is limited literature availble on gene expression markers a...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-MEXP-3589 | biostudies-arrayexpress
TranscriptomicsAttenuation of Global Transcript Changes Induced by Elastase with Symplostatin 5 Cotreatment
Microarray profiling using the Affymetrix GeneChip Human Genome U133 plus 2.0 arrays was performed to comprehensively determine global changes in transcript levels in bronchial epithelial cells following elastase treatment. Elastase caused a significant change in expression (P < 0.05, fold change 1....
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-41600 | biostudies-arrayexpress
GenomicsTargeting Neutrophil Elastase in murine breast cancer tumors
Targeting Neutrophil Elastase in murine breast cancer tumors
PRJNA901508 | ENA
TranscriptomicsSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
During pneumonic plague, the bacterium Yersinia pestis elicits the development of inflammatory lung lesions that continue to expand throughout infection. This lesion development and persistence is poorly understood. Here, we examine spatially distinct regions of lung lesions using laser capture micr...
ORGANISM(S): Mus musculus 
2015-07-13 | E-GEOD-70819 | biostudies-arrayexpress
ProteomicsHuman bladder cancer and colon cancer quatitative MS/MS
We analyzed a set of 40 independently collected tumor tissue/control samples using a label-free quantitation single pass LC-MS/MS approach. In this set, 10 samples originated from a colon tumor (i.e. AC) and 10 from control non-malignant tissue samples (NCA), as well as 10 from BC samples and 10 fro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082886 | MassIVE
TranscriptomicsTargeting Neutrophil Elastase in murine breast cancer tumors
To investigate the function of neutrophil elastase in breast cancer metastasis, as a function of time We then performed gene expression profiling analysis using data obtained from PyMT tumors (N=5 each) that are either WT or knockout for Neutrophil Elastase i.e. NEKO.
ORGANISM(S): Mus musculus 
2023-10-21 | GSE217980 | GEO
ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
GenomicsNeutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
PRJNA830716 | ENA
UnknownMice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.
Not available
S-EPMC1762691 | biostudies-literature
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