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MetabolomicsProteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea

Gastrointestinal bacteria interact with the host and each other through various mechanisms, including the production of extracellular vesicles (EVs). However, the composition and potential roles of EVs released by gut archaea are poorly understood. Here, we study EVs produced by four strains of h...

2025-07-01 | MTBLS12422 | MetaboLights
TranscriptomicsCrosstalk between the effects of extracellular vesicles (Evs) and TNF on U937 human monocyte cell line
Under physiological conditions, extracellular vesicles (EVs) are present simultaneously in the extracellular compartment together with cytokines. Thus, we hypothesized that EVs in combination with cytokines induce different responses of monocyte cells compared to EVs or cytokines alone. Human monocy...
ORGANISM(S): Homo sapiens 
2013-06-19 | E-GEOD-47897 | biostudies-arrayexpress
ProteomicsHost-to-Pathogen Transfer of Neutrophil Components via Extracellular Vesicles Shields Candida albicans from Immune Attack in Human Blood
Neutrophils effectively eliminate Candida albicans from human blood, but a subset of C. albicans escapes their activity and remains extracellular and viable. Here we show that this is independent from known immune-escape traits of this fungal pathogen. Instead, neutrophil-derived extracellular vesic...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD070460 | Pride
Candida albicans Immune evasion Neutrophil-derived extracellular vesicles (evs) Bloodstream infection Complement-dependent opsonization 
UnknownNeutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles.
Not available
S-EPMC7806483 | biostudies-literature
GenomicsChondroprotective functions of neutrophil-derived extracellular vesicles via promoting the production of secreted frizzled related protein 5 in cartilage
Chondroprotective functions of neutrophil-derived extracellular vesicles via promoting the production of secreted frizzled related protein 5 in cartilage
PRJNA1130388 | ENA
GenomicsChondroprotective functions of neutrophil-derived extracellular vesicles via promoting the production of secreted frizzled related protein 5 in cartilage [SFRP5]
Chondroprotective functions of neutrophil-derived extracellular vesicles via promoting the production of secreted frizzled related protein 5 in cartilage [SFRP5]
PRJNA1130401 | ENA
UnknownHigh yield, scalable and remotely drug-loaded neutrophil-derived extracellular vesicles (EVs) for anti-inflammation therapy.
Not available
S-EPMC5516786 | biostudies-literature
TranscriptomicsChondroprotective functions of neutrophil-derived extracellular vesicles via promoting the production of secreted frizzled related protein 5 in cartilage
Neutrophil extracellular vesicles (EVs) are known to play a protective role in arthritic joints by suppressing inflammation and cartilage degeneration. In the current study, we investigated the functional characteristics of EVs derived from stimulated neutrophils and their protective effects in cart...
ORGANISM(S): Homo sapiens 
2024-11-26 | GSE271169 | GEO
UnknownProtocol for the isolation of human neutrophil-derived extracellular vesicles for characterization and functional experimentation.
Not available
S-EPMC12002981 | biostudies-literature
ProteomicsEZH2 inhibition in mesothelioma cells increases the release of extracellular vesicles that skew neutrophils toward a pro-tumor phenotype.
BAP1-deficient pleural mesotheliomas have been shown to be sensitive to inhibition of the histone methyltransferase EZH2 in preclinical settings but only showed modest efficacy in clinical trials. We recently demonstrated that in BAP1-proficient mesothelioma cells, CDKN2A plays a crucial role in res...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD057566 | Pride
Mass spectrometry Pleural mesothelioma Spheroids. Histone methyltransferase ezh2 Cdkn2a Extracellular vesicles 
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