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ProteomicsComparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi
A substantial part of cutaneous malignant melanomas develops from benign nevi. However, the precise molecular events driving the transformation from benign to malignant melanoma are not well understood. We used laser microdissection and mass spectrometry to analyze the proteomes of melanoma subtypes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-28 | PXD044107 | Pride
Human Nevus-associated melanoma Proteomics Microdissection Skin cancer Skin Melanoma subtypes Ffpe Nevi Malignant melanoma 
TranscriptomicsTranscription profiling of human tissue samples to identify novel genes associated with malignant melanoma but not benign melanocytic lesions
A number of melanoma specific genes were identified to differentiate clinical relevant tissue samples containing benign from malignant melanocytes. Experiment Overall Design: 7 normal skin, 18 nevi and 45 melanoma samples
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3189 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human common melanocytic nevi, radial and vertical growth phase melanomas, melanoma metastases and dysplastic nevi
Despite malignant cutaneous melanoma is relatively rare compared to other skin cancers, it is still responsible for 80% of all skin cancer-related deaths. To identify molecular signatures of melanoma progression, excisional biopsies from 18 common melanocytic nevi (CMN), 8 primary radial growth phas...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-12391 | biostudies-arrayexpress
GenomicsProgressive immune activation and negative immunoregulation from common melanocytic nevi to dysplastic nevi to melanoma
Progressive immune activation and negative immunoregulation from common melanocytic nevi to dysplastic nevi to melanoma
PRJNA471357 | ENA
GenomicsMolecular Profiling of Spitz Nevi (SN) in Relation to Nevocellular Nevi (NCN)
Molecular Profiling of Spitz Nevi (SN) in Relation to Nevocellular Nevi (NCN)
PRJNA434073 | ENA
GenomicsCD4+ T cells Reject Benign Melanocytic Nevi
CD4+ T cells Reject Benign Melanocytic Nevi
PRJNA642297 | ENA
TranscriptomicsComparative genomic hybridization to distinguish paraffin-embedded Spitz nevi and melanomas
Not available
ORGANISM(S): Homo sapiens 
2005-01-01 | E-SMDB-2707 | biostudies-arrayexpress
GenomicsMutation signatures in melanocytic nevi reveal characteristics of defective DNA repair
Nevi are common benign melanocytic neoplasms that can be found on any skin location and share many of the genomic hallmarks of melanoma. In our recent report involving whole-exome sequencing of acquired nevi (Stark et al., 2018), ultra-violet radiation (UVR) related somatic mutation signatures (“sig...
EGAS00001004274 | EGA
GenomicsDeconvoluted methylation profiles discriminate between closely related melanocytic nevi
Deconvoluted methylation profiles discriminate between closely related melanocytic nevi
PRJNA1118718 | ENA
TranscriptomicsDiscrimination of dysplastic nevi from common melanocytic nevi by cellular and molecular criteria
Cellular and molecular differences between DNs and CMNs are not completely understood. Using cDNA microarray, quantitative RT-PCR, and immunohistochemistry, we molecularly characterized DNs and analyzed the difference between DNs and CMNs. total RNA was extratced from sliced full thickness tissue s...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-53223 | biostudies-arrayexpress
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