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ProteomicsMembrane prewetting by condensates promotes tight junction belt formation
Time-resolve proximity proteomics of tight junction. To understand how the tight junction belt is assembled and positioned, we combined APEX2 proximity proteomics of the main junctional scaffold protein ZO-1 with a calcium switch tissue formation assay.This combination allowed us to synchronize the ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-05-22 | PXD052221 | Pride
Canis lupus Tight junction Tmt Apex2 Mdck-ii 
UnknownSubstance abuse and inpatient outcomes in inflammatory bowel disease hospitalizations in the United States: a propensity matched analysis.
Not available
S-EPMC9756027 | biostudies-literature
UnknownClinical, morphological and genetic characterization of Brody disease: an international study of 40 patients.
Not available
S-EPMC7009512 | biostudies-literature
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
UnknownUsing coherent X-rays to follow dynamics in amorphous ices.
Not available
S-EPMC9648632 | biostudies-literature
ProteomicsUrinary endogenous peptides as biomarkers for prostate cancer
Prostate cancer (PCa) is one of the most prevalent cancer types in men worldwide. However, the main diagnostic tests available for PCa have limitations and need biopsy for histopathological confirmation of the disease. The prostate-specific antigen (PSA) is the main biomarker used for PCa early dete...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD037031 | Pride
Uromodulin Urine Endogenous peptides Mass spectrometry Biomarkers Prostate cancer 
TranscriptomicsLymphatic vessels arise from a niche of multipotent angioblasts within the floor of the cardinal vein
How cells acquire their fate is a fundamental question in both developmental and regenerative biology. Multipotent progenitors undergo gradual cell fate restriction in response to temporal and positional cues from the microenvironment, the nature of which is far from being clear. In the case of the ...
ORGANISM(S): Danio rerio 
2015-05-21 | E-GEOD-65751 | biostudies-arrayexpress
ProteomicsProteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae — Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation
Hexokinase 2 (Hxk2) of Saccharomyces cerevisiae is a dual function hexokinase, acting as a glycolytic enzyme and being involved in the transcriptional regulation of glucose-repressible genes. Relief from glucose repression is accompanied by phosphorylation of Hxk2 at serine 15, which has been attrib...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-06 | PXD030105 | Pride
Yeast In-gel digestion Saccharomyces cerevisiae Hexokinase 2d gel elctrophoresis Lc-ms/ms 
TranscriptomicsTranscriptomic responses in Arabidopsis thaliana to PIPL3 peptide treatment
In order to investigate possible roles of IDL and PIP/PIPL peptides, the transcriptomic response of Arabidopsis seedlings to treatment with PIPL3 peptide was analysed. PIPL3 (At4g37295) was chosen, as no functional data was available for this peptide; furthermore, PIPL3 was expressed in leaf tissue ...
ORGANISM(S): Arabidopsis thaliana 
2015-07-10 | E-GEOD-66201 | biostudies-arrayexpress
MetabolomicsIntegrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress
OBJECTIVE: Atherosclerotic plaque development is closely associated with the hemodynamic forces applied to endothelial cells (EC). Among these, shear stress (SS) plays a key role in disease development since changes in flow intensity and direction could stimulate an atheroprone or athero...
2019-07-25 | MTBLS739 | MetaboLights
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