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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
ProteomicsDifferential protein expression in new1 knock-out yeast
A label-free quantitative proteomics experiment was performed to study the impact of new1 knock-out on differential protein expression in S. cerevisiae (baker’s yeast).
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-11-26 | PXD055983 | Pride
New1 Lc-ms Yeast Differential expression 
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
Genomics5P-Seq analysis of wt and new1-knockout yeast strain as well as New1:80S pull-down samples
5P-Seq analysis of wt and new1-knockout yeast strain as well as New1:80S pull-down samples
PRJNA954726 | ENA
MetabolomicsRegulatory Role of the VCL/ICAM-1 Pathway in Inflammatory Exudative Damage to the Gas-Blood Barrier in SARS-CoV-2 Infection: New Insights from the Omicron Paradigm
Infections by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from the initial Wildtype (WT) variant in Wuhan, China, to later variants including Omicron, have showcased a diverse spectrum of symptoms. This diversity underscores the need for ongoing exploration into the vir...
2025-02-28 | MTBLS12231 | MetaboLights
Other5P-Seq analysis of wt and new1-knockout yeast strain as well as New1:80S pull-down samples
We present two sets of 5P-Seq experiments: i) comparison of wt and new1-KO S. cerevisiae ii) analysis of New1:80S pulldown samples. Collectively our results unravel codon-dependent nature of ribosomal stalling in S. cerevisiae lacking New1.
ORGANISM(S): Saccharomyces cerevisiae 
2023-04-12 | GSE229473 | GEO
MetabolomicsReactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficie...
2019-05-22 | MTBLS593 | MetaboLights
GenomicsRibosome profiling of NEW1 knock-out of budding yeast Saccharomyces cerevisiae
Ribosome profiling of NEW1 knock-out of budding yeast Saccharomyces cerevisiae
PRJEB27604 | ENA
UnknownA role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.
Not available
S-EPMC7145556 | biostudies-literature
UnknownYeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay.
Not available
S-EPMC12852954 | biostudies-literature
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