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ProteomicsUnique shaping of the chloroplastic iron-sulfur transfer protein NFU1 sustains dark chlorophyll synthesis and fermentation in Chlamydomonas reinhardtii
The sulfur mobilization (SUF) machinery is required for the synthesis of iron-sulfur (Fe- S) clusters and their insertion into client proteins in plastids. The final step relies on several Fe-S cluster transfer proteins, including NIFU-like (NFU) proteins. In this study, we focused on the chloroplas...
ORGANISM(S): Chlamydomonas reinhardtii 
2026-07-07 | PXD070162 | Pride
Iron-sulfur cluster  transfer protein Endonuclease domain  gyi-yig motif  nfu domains  green microalga  chloroplast 
ProteomicsA single mutation in NFU1 gene metabolically reprograms pulmonary artery smooth muscle cells
NFU1 is an iron-sulfur (Fe-S) scaffold protein, involved in Fe-S assembly and transfer to a range of mitochondrial metalloproteins. Patients with the NFU1G208C mutation develop pulmonary arterial hypertension (PAH) with 70% penetrance. Rats with NFU1G206C homozygous mutation demonstrated the PAH phe...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD015022 | Pride
Nfu1 Pulmonary arterial hypertension Hyper-proliferative Liver 
UnknownISCU interacts with NFU1, and ISCU[4Fe-4S] transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1.
Not available
S-EPMC7261492 | biostudies-literature
UnknownPhenotypic continuum of NFU1-related disorders.
Not available
S-EPMC9735368 | biostudies-literature
ProteomicsThe plastidial Arabidopsis thaliana NFU1 delivers [4Fe-4S] clusters to specific client proteins
Proteins incorporating iron-sulfur (Fe-S) cofactors are required for a plethora of metabolic processes. Their maturation depends on three Fe-S cluster assembly machineries located in the cytosol, mitochondria and chloroplasts. After de novo formation on scaffold proteins, Fe-S centers are loaded on ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-06 | PXD015295 | Pride
Arabidopsis 
UnknownNfu1 Mediated ROS Removal Caused by Cd Stress in Tegillarca granosa.
Not available
S-EPMC5741617 | biostudies-literature
UnknownRole of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients.
Not available
S-EPMC5014551 | biostudies-literature
UnknownStructural/Functional Properties of Human NFU1, an Intermediate [4Fe-4S] Carrier in Human Mitochondrial Iron-Sulfur Cluster Biogenesis.
Not available
S-EPMC5166578 | biostudies-literature
UnknownStructural Plasticity of NFU1 Upon Interaction with Binding Partners: Insights into the Mitochondrial [4Fe-4S] Cluster Pathway.
Not available
S-EPMC10388178 | biostudies-literature
UnknownClinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency.
Not available
S-EPMC4394698 | biostudies-literature
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