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TranscriptomicsAutophagy is essential for cardiac morphogenesis during vertebrate development
This study examined the effects of genetic knockdown of autophagy genes on vertebrate cardiac development We performed microarray studies comparing the hearts of control zebrafish embryos to the hearts of embryos with decreased expression of the autophagy genes atg5, becn1 or atg7. The results prov...
ORGANISM(S): Danio rerio 
2014-03-01 | E-GEOD-51541 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Paneth cells from Atg16l1hm mice with CR6 virus
Transcription profiling of Paneth cells from Atg16l1hm mice with CR6 virus
ORGANISM(S): Mus musculus 
2010-04-09 | E-TABM-957 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse Paneth cells from Atg16l1 mutant and wild type strains
Transcription profiling of Paneth cells from Atg16l1hm mice with CR6 virus. Normalized data is provided as an additional file on the FTP site for this experiment.
ORGANISM(S): Mus musculus 
2010-04-12 | E-TABM-958 | biostudies-arrayexpress
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
TranscriptomicsRegulation of monocyte functional heterogeneity by miR-146a
Monocytes and their lineage descendants serve as a central defense system against infection and injury but if uncontrolled can also promote an excessive pathological inflammatory response. Therefore a current research goal is to understand how the organism controls the number and function of monocyt...
ORGANISM(S): Mus musculus 
2012-04-05 | E-GEOD-32370 | biostudies-arrayexpress
TranscriptomicsRegulation of Monocyte Functional Heterogeneity by miR-146a
This SuperSeries is composed of the following subset Series: GSE32364: Murine blood monocyte subsets GSE32370: Regulation of monocyte functional heterogeneity by miR-146a Refer to individual Series
ORGANISM(S): Mus musculus 
2012-04-05 | E-GEOD-32392 | biostudies-arrayexpress
UnknownIntegrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
Not available
S-EPMC5774584 | biostudies-literature
GenomicsEpigenetic programming during monocyte to macrophage differentiation and trained innate immunity
Monocyte differentiation into macrophages represents one of the cornerstone processes in innate host defense. In addition, immunological imprinting of either tolerance or trained immunity after an initial infection determines the functional fate of innate immune cells and the susceptibility of the h...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-58310 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptional profiling of human PBMCs stimulated with Candida albicans and non-fungal inflammatory stimuli
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections, but human anti-fungal immunity remains poorly defined. Expression profiling of Candida-stimulated human peripheral blood mononuclear cells (PBMCs) provides new insights into Candida-specific host defen...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-42606 | biostudies-arrayexpress
TranscriptomicsExpression analysis of human PBMCs stimulated with Borrelia, MDP or Pam3cys.
Analysis examining the effect of the Crohn's disease-associated ATG16L1 polymorphism on the responses to stimulation components derived from various bacteria classes. Expression analysis was performed on RNA extracted from peripheral blood mononuclear cells (PBMCs) from healthy genotyped volunteers ...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-68765 | biostudies-arrayexpress
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